Active Pharmaceutical Ingredients

CAS NO.:61036-62-2

Molecular formula:C77H77N9O31Cl2.R

Molecular weight:

Standard：JP/ EP

Content：≥900ug/mg

Packaging:1KG/Tin

Use to:Glycopeptides

Telicoplanin: An Effective Antibacterial Agent

Telicoplanin is a significant glycopeptide antibiotic used in the management of various bacterial infections.

1. General and Pharmacokinetic Information

Aspect	Details
Source	Produced by Actinoplanes teichomyceticus
Chemical Class	Glycopeptide
Administration	Intravenous injection (for systemic infections), can also be used intramuscularly in some cases
Distribution	Distributes well in most body tissues, including bone, but has limited penetration into the cerebrospinal fluid without inflammation
Metabolism	Undergoes minimal metabolism in the body
Elimination	Primarily excreted unchanged in the urine, with a long elimination half – life of approximately 47 – 100 hours in adults

2. Mechanism of Action

Action

Explanation

Inhibition of Cell Wall Synthesis

Telicoplanin binds to the D – alanyl – D – alanine terminal of the lipid – linked peptidoglycan precursors in the cell wall of Gram – positive bacteria. This binding prevents the transglycosylation and transpeptidation reactions that are essential for the elongation and cross – linking of the peptidoglycan chains. As a result, the cell wall synthesis is disrupted, leading to cell lysis and death of the bacteria.

3. Clinical Applications and Adverse Effects

Category	Details
Clinical Applications	Used mainly for treating severe infections caused by Gram – positive bacteria. It is effective against methicillin – resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Streptococcus pyogenes, and Enterococcus faecalis. Indicated for skin and soft – tissue infections, bloodstream infections, endocarditis, and osteomyelitis.
Adverse Effects	Infusion – related reactions such as rash, pruritus, and rarely anaphylaxis can occur. Nephrotoxicity is a concern, especially with high doses or in patients with pre – existing renal impairment, manifested as increased serum creatinine levels. Thrombocytopenia may also be observed in some patients.

Telicoplanin plays a crucial role in the treatment of Gram – positive bacterial infections, but its use needs to be carefully monitored to manage potential adverse effects.