Tamsulosin HCl
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80018040
CAS NO.106463-17-6
Purity 95%
MDL NumberMFCD00922997
Molecular FormulaC20H28N2O5S.HCl
Molecular Weight 444.9727
Melting point: 228~232°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C20H28N2O5S·HCl<br> Molecular weight: 444.97 |
| Physical Properties | Appearance: White crystalline powder<br> Melting point: Not specified |
| Mechanism of Action | Selective antagonist of α1A and α1D adrenoceptors. Blocks these receptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck, leading to relaxation of smooth muscles and improved urinary flow. |
| Therapeutic Uses | Benign Prostatic Hyperplasia (BPH): Reduces symptoms by improving urine flow and reducing bladder outlet obstruction.<br> Kidney Stones: Helps in the passage of kidney stones.<br> Acute Urinary Retention: Used for treatment. |
| Pharmacokinetics | Absorption: 90% absorbed orally.<br> Distribution: Volume of distribution 16 L after intravenous administration.<br> Metabolism: Metabolized by CYP3A4 and CYP2D6 in the liver.<br> Excretion: 76% excreted in urine, 21% in feces; 8.7% excreted as unchanged tamsulosin. |
| Storage Conditions | Store at room temperature, protect from light and moisture. |
| Safety Information | Side Effects: May cause dizziness, hypotension, or ejaculatory dysfunction.<br> Contraindications: Avoid in patients with hypersensitivity to tamsulosin.<br> Drug Interactions: Use with caution with CYP3A4 inhibitors |
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