Talniflumate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80020400
CAS NO.66898-62-2
Purity 98%
MDL NumberMFCD00866135
Molecular FormulaC21H13F3N2O4
Molecular Weight414.3341
Melting point: 165~166°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₂₁H₁₃F₃N₂O₄<br>- Molecular Weight: 414.3 g/mol |
| Physical Properties | – Appearance: White to off-white powder |
| Mechanism of Action | – Strong and selective inhibitor of the core mucin-synthesizing enzyme GCNT3 (core 2 b-1,6 N-acetylglucosaminyltransferase).<br>- Blocks prostaglandin synthesis by cyclooxygenases, aiding in pain and inflammation management.<br>- Acts as a calcium-activated chloride channel (CaCC) blocker. |
| Clinical Uses | – Used for treating inflammatory disorders such as rheumatoid arthritis and osteoarthritis.<br>- Studied for the management of cystic fibrosis.<br>- Investigated for improving the response of pancreatic tumors to chemotherapy drugs like gefitinib. |
| Pharmacokinetics | – Metabolized to its prodrug, niflumic acid, which has potent analgesic and anti-inflammatory effects.<br>- Undergoes extensive first-pass metabolism in the liver.<br>- Biological half-life is approximately 2 hours. |
| Safety Information | – Strongly bound to plasma proteins, with high bioavailability (100%) in humans.<br>- Store in a cool, dry place, protected from moisture. |
| Synonyms | – Somalgen, Lomucin, Talniflumato, Talniflumatum |
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