LCZ696 Intermediate 3, chemically identified as (2R,4S)-ethyl 5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride, is a critical chiral intermediate in the synthesis of LCZ696 (Entresto®), a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) used to treat heart fail…
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