LCZ696 Intermediate II, chemically identified as (R,E)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid, is a critical synthetic intermediate in the production of LCZ696 (Entresto®), a medication used to treat heart failure and hypertension. This compound serv…