Active Pharmaceutical Ingredients

Catalog ID80071718

CAS NO.557795-19-4

Purity 98%

MDL NumberMFCD09260778

Molecular FormulaC22H27FN4O2

Molecular Weight398.479

Melting point: 245~249°C

Item	Information
Mechanism of Action	Sunitinib is a multi-targeted receptor tyrosine kinase (RTK) inhibitor. It inhibits several key receptors, including vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR), which are involved in tumor growth and angiogenesis.
Indications	– Treatment of gastrointestinal stromal tumors (GIST) in patients who are intolerant of or have developed resistance to imatinib.<br>- Advanced renal cell carcinoma (RCC) as first-line therapy.<br>- Advanced pancreatic neuroendocrine tumors (pNET) in adults.<br>- RCC adjuvant therapy to reduce the risk of recurrence.
Dosage Forms	Available as oral capsules in strengths of 12.5 mg, 25 mg, 37.5 mg, and 50 mg.
Dosage	– For GIST and RCC: 50 mg once daily for 4 weeks, followed by a 2-week break (4/2 schedule) until disease progression or unacceptable toxicity.<br>- For RCC adjuvant therapy: Same dosage for 9 cycles of 6 weeks each.<br>- For pNET: 37.5 mg once daily continuously until disease progression.
Common Side Effects	Fatigue, diarrhea, mucositis, nausea, decreased appetite, vomiting, abdominal pain, hand-foot syndrome, hypertension, bleeding events, and altered taste.
Serious Side Effects	Liver toxicity, cardiovascular events, QT prolongation, hypertension, tumor lysis syndrome, thrombotic microangiopathy, proteinuria, skin toxicity, and reversible posterior leukoencephalopathy syndrome.
Drug Interactions	– Strong CYP3A4 inhibitors (e.g., ketoconazole) may increase sunitinib levels.<br>- Strong CYP3A4 inducers (e.g., rifampin) may decrease sunitinib levels.<br>- Caution with drugs that prolong QT interval.
Special Precautions	Regular liver function monitoring, blood pressure monitoring, and ECG monitoring for QT interval. Avoid grapefruit or grapefruit juice.
Pregnancy and Lactation	Not recommended during pregnancy or breastfeeding due to potential harm to the fetus or infant.

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