Sugammadex sodium
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Sugammadex sodium γ-Cyclodextrin, 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-, sodium salt (1:8)
Catalog ID100883
CAS NO.343306-79-6
Purity 95%
MDL NumberMFCD09954145
EINEC Molecular FormulaC72H104O48S8.8Na
Molecular Weight2178.01
| Category | Content |
|---|---|
| Generic Name | Sugammadex Sodium |
| Brand Name | Bridion |
| Chemical Formula | C72H104Na8O48S8 |
| Mechanism of Action | Sugammadex is a modified gamma-cyclodextrin that encapsulates neuromuscular blocking drugs (NMBDs) such as rocuronium and vecuronium, preventing them from acting at the acetylcholine receptor. This rapidly reverses neuromuscular blockade. |
| Indications | Approved for antagonism of rocuronium- and vecuronium-induced neuromuscular blockade in adults. |
| Dosage Forms | Intravenous solution |
| Administration | Rapid intravenous injection (within 10 seconds) after the reappearance of the second twitch in the train-of-four. |
| Side Effects | – Common: Headache, nausea, vomiting, injection site pain, dizziness.<br>- Serious: Hypotension, bradycardia, anaphylaxis, respiratory complications. |
| Contraindications | Hypersensitivity to sugammadex sodium or any excipients. |
| Special Populations | – Not recommended in severe renal impairment or dialysis patients.<br>- No dose adjustment needed in mild-to-moderate renal or hepatic impairment. |
| Developer | Merck & Co. (Market as Bridion) |
| Approval Date | Approved by the FDA in 2015 |
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