Active Pharmaceutical Ingredients

Catalog ID92616

CAS NO.19983-44-9

Purity 98% M

DL NumberMFCD00173799

Colecular formula C8H5NO4S

Molecular weight 211.195

Melting point: 184°C

Boiling point: 461.1℃ at 760mmHg

Flash point: 232.6℃

Category	Content
Name	Stattic (STAT3 Inhibitor V)
Chemical Formula	C8H5NO4S
CAS Number	19983-44-9
Molecular Weight	211.19 g/mol
Mechanism of Action	Stattic is a small molecule inhibitor of STAT3 that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. It blocks the binding of high-affinity phosphopeptides to the SH2 domain of STAT3.
Target Pathways	– JAK/STAT signaling pathway<br>- Apoptosis pathway
Biological Activity	– In Vitro: Stattic inhibits STAT3 phosphorylation and reduces cell viability in various cancer cell lines, including MDA-MB-231, MDA-MB-435S, and PANC-1.<br>- In Vivo: Demonstrates antitumor activity in mouse models, with significant inhibition of tumor growth associated with decreased phospho-STAT3 levels.
Applications	– Research: Used to study the role of STAT3 in cancer and inflammatory diseases.<br>- Medicine: Investigated for potential use in treating cancers driven by STAT3 activation.
Physical Properties	– Appearance: White solid.<br>- Solubility: Soluble in DMSO (10.6 mg/mL, 50 mM) and ethanol (1.1 mg/mL, 5 mM).<br>- Storage: Powder (-20°C for 3 years); in solvent (-80°C for 1 year).
Safety	– Handle with care to avoid contact with skin and eyes.<br>- Store in a cool, dry place.
Purity	≥99.64%

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