Stattic
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID92616
CAS NO.19983-44-9
Purity 98% M
DL NumberMFCD00173799
Colecular formula C8H5NO4S
Molecular weight 211.195
Melting point: 184°C
Boiling point: 461.1℃ at 760mmHg
Flash point: 232.6℃
| Category | Content |
|---|---|
| Name | Stattic (STAT3 Inhibitor V) |
| Chemical Formula | C8H5NO4S |
| CAS Number | 19983-44-9 |
| Molecular Weight | 211.19 g/mol |
| Mechanism of Action | Stattic is a small molecule inhibitor of STAT3 that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. It blocks the binding of high-affinity phosphopeptides to the SH2 domain of STAT3. |
| Target Pathways | – JAK/STAT signaling pathway<br>- Apoptosis pathway |
| Biological Activity | – In Vitro: Stattic inhibits STAT3 phosphorylation and reduces cell viability in various cancer cell lines, including MDA-MB-231, MDA-MB-435S, and PANC-1.<br>- In Vivo: Demonstrates antitumor activity in mouse models, with significant inhibition of tumor growth associated with decreased phospho-STAT3 levels. |
| Applications | – Research: Used to study the role of STAT3 in cancer and inflammatory diseases.<br>- Medicine: Investigated for potential use in treating cancers driven by STAT3 activation. |
| Physical Properties | – Appearance: White solid.<br>- Solubility: Soluble in DMSO (10.6 mg/mL, 50 mM) and ethanol (1.1 mg/mL, 5 mM).<br>- Storage: Powder (-20°C for 3 years); in solvent (-80°C for 1 year). |
| Safety | – Handle with care to avoid contact with skin and eyes.<br>- Store in a cool, dry place. |
| Purity | ≥99.64% |
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