Spironolactone CAS 52-01-7
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Chemical Name: Spironolactone
CAS No.: 52-01-7
Assay: ≥ 99.0%
Appearance:white powder
Spironolactone More Details：
Specification:
Appearance white powder
Assay% 99%
molecular formula C24H32O4S
molecular weight 416.57
melting point 207-208°C
Boiling point 504.87°C
Density 1.1061
Spironolactone Usage：
Used as a diuretic
Spironolactone Packaging and Shipping：
25kg/ drum，25kg/bag or as per buyer requirement.
Spironolactone Storage：
Store in a dry and ventilated warehouse， avoid sunshine , keep away from fires and heating.
| Item | Content |
|---|---|
| Introduction | Spironolactone (CAS No.: 52-01-7) is a potassium-sparing diuretic used to treat conditions such as edema, hypertension, and hyperaldosteronism. It is also used for its anti-androgenic properties. |
| Chemical Properties | – Molecular Formula: C₂₄H₃₂O₄S<br>- Molecular Weight: 416.58<br>- Appearance: White to yellow-white powder.<br>- Melting Point: 207-208°C.<br>- Solubility: Practically insoluble in water, soluble in ethanol. |
| Mechanism of Action | Spironolactone acts as a competitive antagonist to aldosterone, reducing sodium reabsorption and potassium excretion in the kidneys. It also inhibits androgen synthesis. |
| Medical Uses | – Edema (e.g., due to heart failure, cirrhosis, nephrotic syndrome)<br>- Hypertension<br>- Primary hyperaldosteronism<br>- Androgen-dependent conditions (e.g., hirsutism, acne). |
| Storage Conditions | Store at 2-8°C. |
| Safety Information | – Toxicity: Intraperitoneal LD50 in rats: 277 mg/kg.<br>- Pregnancy and Lactation: Limited data suggest it is acceptable for use during breastfeeding.<br>- Side Effects: Hyperkalemia, gynecomastia, menstrual irregularities. |
| Regulatory Status | – FDA-Approved Uses: Edema, hypertension, hyperaldosteronism.<br>- IARC Classification: Group 3 (not classifiable as to its carcinogenicity to humans) |
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