Active Pharmaceutical Ingredients

Chemical Name: Spironolactone

CAS No.: 52-01-7

Assay: ≥ 99.0%

Appearance:white powder

Spironolactone More Details：

Specification:

Appearance white powder

Assay% 99%

molecular formula C24H32O4S

molecular weight 416.57

melting point 207-208°C

Boiling point 504.87°C

Density 1.1061

Spironolactone Usage：

Used as a diuretic

Spironolactone Packaging and Shipping：

25kg/ drum，25kg/bag or as per buyer requirement.

Spironolactone Storage：

Store in a dry and ventilated warehouse， avoid sunshine , keep away from fires and heating.

Item	Content
Introduction	Spironolactone (CAS No.: 52-01-7) is a potassium-sparing diuretic used to treat conditions such as edema, hypertension, and hyperaldosteronism. It is also used for its anti-androgenic properties.
Chemical Properties	– Molecular Formula: C₂₄H₃₂O₄S<br>- Molecular Weight: 416.58<br>- Appearance: White to yellow-white powder.<br>- Melting Point: 207-208°C.<br>- Solubility: Practically insoluble in water, soluble in ethanol.
Mechanism of Action	Spironolactone acts as a competitive antagonist to aldosterone, reducing sodium reabsorption and potassium excretion in the kidneys. It also inhibits androgen synthesis.
Medical Uses	– Edema (e.g., due to heart failure, cirrhosis, nephrotic syndrome)<br>- Hypertension<br>- Primary hyperaldosteronism<br>- Androgen-dependent conditions (e.g., hirsutism, acne).
Storage Conditions	Store at 2-8°C.
Safety Information	– Toxicity: Intraperitoneal LD50 in rats: 277 mg/kg.<br>- Pregnancy and Lactation: Limited data suggest it is acceptable for use during breastfeeding.<br>- Side Effects: Hyperkalemia, gynecomastia, menstrual irregularities.
Regulatory Status	– FDA-Approved Uses: Edema, hypertension, hyperaldosteronism.<br>- IARC Classification: Group 3 (not classifiable as to its carcinogenicity to humans)