Sodium Hyaluronate (CAS 9067-32-7): A Multifunctional Biopolymer

Introduction

Sodium Hyaluronate (SH), CAS number 9067-32-7. is a glycosaminoglycan polymer derived from hyaluronic acid (HA) by sodium salt formation. It is a natural component of human connective tissues, known for its exceptional biocompatibility, viscosity, and moisture-retention properties. SH is widely used in medicine, cosmetics, and food industries due to its non-immunogenic and non-toxic nature.

Key Properties and Specifications

Parameter	Details
CAS Number	9067-32-7
Molecular Formula	(C₁₄H₂₀NNaO₁₁)ₙ (repeating unit)
Molecular Weight	~403.31 g/mol (monomer); 50.000–3.900.000 g/mol (polymer)
Appearance	White to off-white powder or fibrous solid, odorless, hygroscopic
Solubility	Soluble in water; insoluble in ethanol, acetone, or ether
pH Range	5.5–8.5 (2 g/L solution at 25°C)
Storage Conditions	-20°C, sealed, protected from moisture and light
Origin	Extracted from rooster combs, bovine eyes, or microbial fermentation

Applications and Uses

Medical Applications

Orthopedics: Injectable SH is used to treat osteoarthritis, reducing joint pain and improving mobility by restoring synovial fluid viscosity.

Ophthalmology: Employed in cataract and corneal surgeries as a viscoelastic agent to protect ocular tissues and maintain anterior chamber depth.

Wound Healing: Promotes tissue repair by providing a hydrated environment and reducing inflammation.

Cosmetics

Skincare: Added to moisturizers, serums, and creams to enhance skin hydration, elasticity, and smoothness.

Anti-aging: Helps reduce wrinkles by supporting collagen synthesis and skin barrier function.

Food Industry

Approved as a food additive in some regions, SH is used in beverages, dairy products, and confectionery to improve texture and shelf life.

Industrial Uses

Biomaterials: Used in drug delivery systems, tissue engineering scaffolds, and biosensors due to its biocompatibility.

Safety Information

Hazard Statements	Safety Precautions
H36/37/38	Avoid contact with eyes, skin, or clothing. Wear protective gloves and eyewear.
Storage	Keep in a cool, dry place away from direct sunlight and oxidizing agents.
Toxicity	LD50 (oral, rabbit) > 1 g/kg, indicating low acute toxicity.

Conclusion

Sodium Hyaluronate (CAS 9067-32-7) is a versatile biopolymer with applications spanning healthcare, cosmetics, and food. Its unique physicochemical properties make it invaluable for enhancing product quality and functionality across diverse industries.