Sodium hyaluronate CAS No.:9067-32-7
Biochemical Materials 2025-03-04
Sodium Hyaluronate (CAS 9067-32-7): A Multifunctional Biopolymer
Introduction
Sodium Hyaluronate (SH), CAS number 9067-32-7. is a glycosaminoglycan polymer derived from hyaluronic acid (HA) by sodium salt formation. It is a natural component of human connective tissues, known for its exceptional biocompatibility, viscosity, and moisture-retention properties. SH is widely used in medicine, cosmetics, and food industries due to its non-immunogenic and non-toxic nature.
Key Properties and Specifications
| Parameter | Details |
|---|---|
| CAS Number | 9067-32-7 |
| Molecular Formula | (C₁₄H₂₀NNaO₁₁)ₙ (repeating unit) |
| Molecular Weight | ~403.31 g/mol (monomer); 50.000–3.900.000 g/mol (polymer) |
| Appearance | White to off-white powder or fibrous solid, odorless, hygroscopic |
| Solubility | Soluble in water; insoluble in ethanol, acetone, or ether |
| pH Range | 5.5–8.5 (2 g/L solution at 25°C) |
| Storage Conditions | -20°C, sealed, protected from moisture and light |
| Origin | Extracted from rooster combs, bovine eyes, or microbial fermentation |
Applications and Uses
Medical Applications
Orthopedics: Injectable SH is used to treat osteoarthritis, reducing joint pain and improving mobility by restoring synovial fluid viscosity.
Ophthalmology: Employed in cataract and corneal surgeries as a viscoelastic agent to protect ocular tissues and maintain anterior chamber depth.
Wound Healing: Promotes tissue repair by providing a hydrated environment and reducing inflammation.
Cosmetics
Skincare: Added to moisturizers, serums, and creams to enhance skin hydration, elasticity, and smoothness.
Anti-aging: Helps reduce wrinkles by supporting collagen synthesis and skin barrier function.
Food Industry
Approved as a food additive in some regions, SH is used in beverages, dairy products, and confectionery to improve texture and shelf life.
Industrial Uses
Biomaterials: Used in drug delivery systems, tissue engineering scaffolds, and biosensors due to its biocompatibility.
Safety Information
| Hazard Statements | Safety Precautions |
|---|---|
| H36/37/38 | Avoid contact with eyes, skin, or clothing. Wear protective gloves and eyewear. |
| Storage | Keep in a cool, dry place away from direct sunlight and oxidizing agents. |
| Toxicity | LD50 (oral, rabbit) > 1 g/kg, indicating low acute toxicity. |
Conclusion
Sodium Hyaluronate (CAS 9067-32-7) is a versatile biopolymer with applications spanning healthcare, cosmetics, and food. Its unique physicochemical properties make it invaluable for enhancing product quality and functionality across diverse industries.
