Sodium Carboxymethyl Cellulose CAS 9004-32-4
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Category：Food Additives Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Sodium carboxymethyl cellulose can be used as a thickener, stabilizer, and emulsifier. It is an ideal food additive in the food industry and can be widely used in the production of various foods.
Names and Identifiers
| Name | Carboxymethylcellulose sodium |
| Synonyms | CMC CMCNA Cellex CMC-Na cmc sodium acetic acid cellulose gum carbose sodium cmc-4lf sodium cmc sodium salt carmelosa sodium carmellose sodium carmellosum sodium colloresine sodium croscarmellose sodium Aquacide I, Calbiochem croscarmellosum sodium Aquacide II, Calbiochem cellulose gum 7h sodium celluloseglycolic acid sodium Carboxymethylcellulose sodium Carboxy Methylcellulose Sodium sodium carboxymethyl cellulose carboxymethylcellulosum sodium carboxymethyl cellulose sodium carboximethylcellulosum sodium carboxy-methyl cellulose sodium carboxyl methyl cellulose sodium Carboxyl Methyl Cellulose sodium cellulose carboxymethylate sodium cellulose, (carboxymethyl) sodium cellulose carboxymethyl ether sodium SCMC(SODIUM CARBOXY METHYL CELULLOSE Carboxymethyl cellulose, sodium salt carboxymethyl cellulose ether sodium SODIUM CARBOXY METHYL CELLULOSE (CMC) cellulose carboxymethyl ether, sodium 2,3,4,5,6-pentahydroxyhexanal sodium Cellulose carboxymethyl ether, sodium carboxymethylated cellulose pulp sodium cellulose, ether with glycolic acid sodium |
| CAS | 9004-32-4 117385-93-0 12624-09-8 198084-97-8 247080-55-3 37231-14-4 37231-15-5 404943-62-0 454679-81 |
| EINECS | 618-378-6 |
| InChI | InChI=1/C6H12O6.C2H4O2.Na/c7-1-3(9)5(11)6(12)4(10)2-8;1-2(3)4;/h1,3-6,8-12H,2H2;1H3,(H,3,4) |
9004-32-4 – Physico-chemical Properties
| Molecular Formula | C6H7O2(OH)2CH2COONa |
| Molar Mass | 265.204 |
| Density | 1,6 g/cm3 |
| Melting Point | 274°C (dec.) |
| Boling Point | 527.1°C at 760 mmHg |
| Flash Point | 286.7°C |
| Water Solubility | soluble |
| Solubility | H2O: 20mg/mL, soluble |
| Vapor Presure | 2.59E-13mmHg at 25°C |
| Appearance | White or yellow solid |
| Color | White to light yellow |
| Odor | Odorless |
| Merck | 14,1829 |
| pKa | 4.30(at 25℃) |
| PH | pH (10g/l, 25℃) 6.0～8.0 |
| Storage Condition | room temp |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| MDL | MFCD00081472 |
| Physical and Chemical Properties | Melting Point: 300°C
water-soluble: soluble commonly used sodium salt. White flocculent powder, odorless, tasteless, non-toxic. Soluble in water, the formation of transparent colloidal liquid, the solution is neutral. Stable to light and heat. Hygroscopic. Insoluble in acid, cresol, ethanol, acetone, chloroform, benzene, etc., difficult to dissolve in methanol, ether. A cellulose derivative having a carboxymethyl substituent is prepared by treating the cellulose with sodium hydroxide to form alkali cellulose and then reacting with monochloroacetic acid. The glucose unit constituting the cellulose has three hydroxyl groups that can be substituted, and thus products with different degrees of substitution can be obtained. Average per 1g of dry weight of 1mmol of human carboxymethyl, in water and dilute acid insoluble, but can swell, for ion exchange chromatography. Carboxymethyl pKa is about 4 in pure water and about 0.5 in 3.5 mol/L NaCl. Carboxymethyl pKa is a weakly acidic cation exchanger and is usually used for the separation of neutral and basic proteins at a pH of 4 or higher. More than 40% of the hydroxyl group is carboxymethyl replacement can be dissolved in water to form a stable high viscosity colloidal solution. The pharmaceutical industry selects CMC with appropriate viscosity as a binder, a disintegrant, a suspending agent for a tablet, and the like. The food industry uses CMC with high degree of replacement as thickener for ice cream, canned food, quick-cooked surface, foam stabilizer for beer, etc. Widely used in printing and dyeing, pesticide processing, medicine, paper making, coatings, ceramics, petroleum, food and other industries as sizing agents, thickeners, emulsifiers, emulsion stabilizers, adhesives, film forming agents. |
| Use | Widely used as thickening agent, suspending agent, binder, protective colloid in the pharmaceutical, chemical, food industry |
9004-32-4 – Risk and Safety
| Risk Codes | 40 – Limited evidence of a carcinogenic effect |
| Safety Description | 24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | FJ5950000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 39123100 |
| Toxicity | LD50 oral in rabbit: > 27gm/kg |
Reference Information
in the sample according to the following formula
| FEMA | 2239 | CARBOXYMETHYLCELLULOSE |
| pH range of acid-base indicator discoloration | 6.5 – 8.5 |
| trait | sodium carboxymethyl cellulose (CMC), a carboxymethylated derivative of cellulose, also known as cellulose gum, it is an anionic cellulose ether, which is the most important ionic cellulose gum. It is an anionic polymer compound usually prepared by the reaction of natural cellulose with caustic and monochloroacetic acid. The molecular weight of the compound ranges from thousands to millions. CMC is white or milky white fibrous powder or granules, density 0.5-0.7g/cm3, almost odorless, tasteless, hygroscopic. Easily dispersed in water to form a transparent colloidal solution, insoluble in organic solvents such as ethanol. 1% aqueous solution pH 6.5~8.5, when pH>10 or <5, the viscosity of mucilage decreased significantly, the best performance at pH = 7. For thermal stability, the viscosity rises rapidly below 20 ℃, and changes slowly at 45 ℃, and the colloid can be denatured and the viscosity and performance are obviously decreased by heating above 80 ℃ for a long time. Soluble in water, the solution is transparent; Very stable in alkaline solution, acid is easy to hydrolysis, pH value of 2-3 when there will be precipitation, polyvalent metal salt will also react to sink. Solid CMC is stable to light and room temperature, and can be stored for a long time in a dry environment. |
| properties | sodium carboxymethyl cellulose properties are as follows: 1. Moisture absorption characteristics, the degree of moisture absorption and atmospheric temperature and relative humidity, when reaching equilibrium, no longer moisture absorption. CMC aqueous solution has excellent binding, thickening, emulsification, suspension, film formation, protective colloid, moisture retention, resistance to enzymatic hydrolysis and metabolic inert properties. 3. When CMC aqueous solution meets with tin, silver, aluminum, lead, iron, copper and some heavy metals, precipitation reaction will occur; When CMC aqueous solution coexists with calcium, magnesium and salt, precipitation will not occur, however, the viscosity of the CMC aqueous solution is reduced. When an aqueous CMC solution encounters an acid, an acidic CMC precipitate is precipitated. But acid-resistant CMC has a certain resistance to acid solution. 4. Solubility: CMC aqueous solution with water-soluble animal glue, glycerol glycol, sorbitol, Arabic |
| Application | sodium carboxymethyl cellulose can be used as thickener, stabilizer, emulsifier. The specific application fields are as follows: 1. The application of CMC in food food CMC has the characteristics of thickening, emulsification, excipient, water retention, stability and the like. Adding CMC in food can reduce the production cost of food, improve the food quality, improve the taste of food, and prolong the shelf life of food. It is an ideal food additive in the food industry, can be widely used in a variety of solid and liquid beverages, cans, candy, cakes, meat products, biscuits, instant noodles, rolls, boiled food, frozen snack food and soy milk, yogurt, peanut milk, fruit tea, in the production of fruit juices and other foods. CMC has different uses and amounts in different foods. 2. The use of CMC in the pharmaceutical industry: in the pharmaceutical industry can be used for |
| content analysis | The Percentage Content of sodium carboxymethylcellulose is obtained by subtracting the percentages of sodium chloride and sodium glycolate described below by 100. The sample was weighed accurately for about 5g of sodium chloride content, transferred to a 250m1 beaker, added with 50ml of water and 5ml of 30% hydrogen peroxide, heated on a steam bath for 20min, and stirred occasionally until completely dissolved. Cooling, using silver sulfate and mercury sulfate potassium sulfate electrode, and stirring, add water 0.05 mL and nitric acid 10ml, and then with mol/L silver nitrate titration to the end point of the potential. Calculate the percentage content of sodium chloride in the sample as follows: (584.4Vc)/(100-6)ω where V and c are the volume (m1) and concentration (mol/L) of silver nitrate consumed; 6 is the measured loss on drying; Ω is the sample mass (g);584.4 is the molecular weight of sodium chloride. Sodium glycolate content a sample of about 500mg is accurately weighed and transferred into a 100ml beaker, first moistened with 5ml of glacial acetic acid followed by 5ml of water, and then stirred with a glass rod to a solution (typically about 15min). 50ml of acetone and then 1g of sodium chloride were added slowly with stirring, and the mixture was stirred for several minutes to precipitate all the sodium carboxymethylcellulose. Filter through a soft coarse Porous Filter paper which has been wetted with a small amount of acetone, collect the filtrate into a 100ml volumetric flask, transfer the filter residue to the filter paper with 30ml of acetone and rinse the filter residue, then dilute with acetone, mix well after volume determination. Prepare the standard solution as follows: weigh 100mg of glycolic acid in the desiccator overnight at room temperature accurately, put the person in a 100ml volumetric flask, dissolve with water, Mix well after volume determination. The liquid should be used within 30 days. The solutions were transferred into four 1.0 mL volumetric flasks, 2.0 mL, 3.0 ML and ML, respectively, and water was added to about 5ml, followed by addition of 5ml of glacial acetic acid, followed by dilution with acetone and volume determination. Take 2.0ml of the above-mentioned sample solution and 2.0ml of each standard solution, and transfer them into five 25ml volumetric flasks respectively, and prepare an empty white bottle containing ml of acetone solution each containing 5% of glacial acetic acid and water. Each volumetric flask was left uncapped for 20min on a boiling water bath to remove acetone, removed, and cooled. 5.0ml of 2, 7-dihydroxynaphthalene test solution (TS-85) was added to each bottle, and then 15ml was added after strong mixing, followed by strong mixing. Small piece of thin aluminum cover was taken. The volumetric flask was placed vertically in a boiling water bath for 20min, then removed, cooled, and mixed with sulfuric acid. With an appropriate spectrophotometer, with the blank liquid as the contrast, the absorbance of each liquid is measured at 540nm, and the standard curve is drawn according to the absorbance of the standard liquid, then calculate the mass (mg) of glycolic acid in the sample according to the standard curve and the absorbance of the sample, and then calculate the |
| toxicity | ADI is not specified (FAO/WHO,2001). LD50 (rat, oral) 27g/kg. GRAS(FDA,§ 182.1745,2000). |
| usage limit | GB 2760-96(g/kg): instant noodles 5; Non-solid beverages 1.2; Ice sticks, ice creams, ice cream, cakes, biscuits, jelly, puffed food, GMP. FAO/WHO(1984,g/kg): canned sardines, mackerel 20; Ready-to-eat broth, 4000 mg/kg; Shannon cheese, cream 5, melted cheese 8, flavoring mayonnaise 5000rag/kg. |
| Use | as emulsion stabilizer and thickener. China’s provisions can be used for instant noodles, the maximum use of 5g/kg; In beverages (excluding solid beverages) the maximum use of 1.2g/kg; In biscuits, puffed food, ice sticks, ice creams, cakes and jelly, according to the production needs of the appropriate amount of use. thickeners, stabilizers; Tissue improvers; Gelling agents; Non-nutritive bulking agents; Water movement control agents; Foam stabilizers; Reduce fat adsorption. Because of its viscosity, stability, protective glue, film formation, etc., for ice cream to improve water retention and organizational structure (0.3% ~ 0.5%). But need to be combined with sodium alginate and so on. It is used to make the product uniform, the structure is improved, the moisture is easily controlled, and the operation is easy. Add to the jam, cream, peanut White, etc. can improve the spread. The dosage of jam and seasoning sauce is 0.5% ~ 1%. Bread, Cake, etc. in wheat add 0.1%, can prevent moisture evaporation, aging. It is still used as a solid agent for powdered oil, perfume and the like, and its dosage is 20%-60% (it is prepared by mixing human Oil, perfume and the like in CMC aqueous solution, fully emulsifying, drying and pulverizing). A foam stabilizer for beer. Fruits and vegetables, eggs and the like are coated and dried with 2% to 3% CMC solution containing p-hydroxybenzoate to maintain flavor and prevent mildew. After absorbing water, the swelling is strong, not digested, and can be used for biscuits and other weight loss foods. widely used as thickener, suspending agent, binder, protective colloid in medicine, daily chemical and food industries used in oil drilling, textile printing and dyeing used for mud stabilizer, textile pulp, paper-making reinforcing agent and adhesive for oil and gas drilling used for washing, cigarette, construction, used in textile sizing, drilling and so on used as fluid loss reducer for water-based drilling fluid, which has a certain viscosity increasing effect. it can be used for addition of a reinforcing agent to a slurry, for surface sizing, and for use as a viscosity modifier during coating of processed paper. The greatest use of CMC is in the formulation of soaps and synthetic detergents, with approximately 1% CMC added to heavy grade cleaners to prevent the reprecipitation of wash-out stains on fabrics. Secondly, it is used as a suspension stabilizer for drilling mud in the petroleum industry. In the paper industry, it can be used as an additive to improve the longitudinal strength and smoothness of the paper, in the food industry, it is used as a thickener, emulsion stabilizer and ice cream ice crystal inhibitor; In the textile industry, it is used as a thickener for slurry and printing and dyeing pulp; In the pharmaceutical industry, it can be used as an emulsion stabilizer for injection, binders and film-forming agents for tablets; Used as thickeners in cosmetics, ceramics, etc. The toxicity test on CMC showed that there was no physiological activity in oral and skin contact, and no toxicity was found even at a dose of 10g/kg in mice. The Food and Agriculture Organization of the United Nations and the World Health Organization (WHO) special committee also confirmed the safety of the product, and set the daily allowance (ADI) of 0-30mg/kg. polyanionic cellulose (PAC) is a water-soluble cellulose ether derivative prepared by chemical modification of natural cellulose, which is an important water-soluble cellulose ether, its sodium salt is usually used. Polyanionic cellulose has good heat stability and salt tolerance, strong antibacterial. The slurry fluid prepared by this product has good water loss reduction, inhibition and high temperature resistance. It is widely used in oil drilling, especially in salt water wells and offshore oil drilling. PAC-LV: low-viscosity polyanionic cellulose. |
| production method | carboxymethyl cellulose is produced by reacting cellulose with sodium hydroxide to produce alkali cellulose, it is then obtained by carboxymethylation with monochloroacetic acid. The preparation method can be classified into a solvent method in which a reaction is carried out in water as a medium and a solvent method in which a reaction is carried out in a solvent such as isopropanol, ethanol or acetone. The refined cotton, caustic soda, alcohol mixture and chloroacetic acid alcohol solution are added together to a kneader for alkalization and etherification. Then it is neutralized with hydrochloric acid, washed with alcohol, then dried and crushed to obtain the product. The defatted and bleached cotton thread was immersed in 35% thick alkali solution for about 30 min and removed. Liquid alkali can be recycled. After soaking, the short line of cotton is weighed to the plate press, and the alkali solution is pressed out at a pressure of 14 MPa to obtain alkalized cotton. Put the alkalized cotton into the etherification kettle, add 15 parts of alcohol, slowly add chloroacetic acid alcohol solution under stirring, and complete at 30 ℃ for 2 h, after the addition, the etherified cotton was obtained by stirring at 40 °c for 3 h. Add 70% parts of alcohol (120) to etherified cotton, stir for 0.5 h, and add hydrochloric acid to adjust the pH to 7. After washing twice with alcohol, the alcohol was filtered off, air-dried at 80 ° C. And pulverized to obtain a finished product. Products with low degree of substitution (<0.4) and medium degree of substitution (0.4~1.2) can be produced according to the ratio of ingredients. The cellulose is treated with sodium hydroxide to form alkali cellulose, which is mixed with sodium monochloroacetate and aged for several days (20~30 ℃) to obtain a product usually refined cotton is used as raw material, reaction with sodium hydroxide to produce alkali cellulose, and then carboxymethylated with chloroacetic acid to produce a finished product. (C6H9O4OH)n + nNaOH →(C6H9O4ONa)n[ClCH2COOH]→(C6H9O4OCH2COONa)n The process used in China has the traditional water medium and the solvent method with organic solvent as the reaction medium. The traditional water medium method uses 18% ~ 19% of the alkali liquid spray kneading machine, in 30~35 degrees Celsius to make the refined cotton alkaline to produce alkali cellulose, Kneading etherification was then performed with solid sodium chloroacetate. The first 1~2H temperature control in 35 deg C; After 1H temperature control in 45~55 deg C. After a period of aging (complete etherification), the product is dried and pulverized. Solvent method refined cotton in the kneader, alkali solution according to a certain flow rate into the kneader, fully expanded cellulose, while adding the right amount of ethanol, alkalization temperature control at 30~40 ℃, time 15~25min. After complete alkalization, chloroacetic acid ethanol solution was sprayed and etherified at 50~60 ℃ for 2H. Then the hydrochloric acid ethanol solution is neutralized and washed to remove sodium chloride, and the alcohol is removed with a centrifuge to remove water, and finally dried and pulverized to obtain a finished product. |
| category | toxic substances |
| toxicity grade | low toxicity |
| Acute toxicity | oral-rat LD50: 27000 mg/kg; Oral-mouse LD50: > 27000 mg/kg |
| flammability hazard characteristics | flammable, spicy and irritating smoke containing sodium oxide emitted from fire scene |
| storage and transportation characteristics | warehouse low temperature, ventilation, dry |
| extinguishing agent | water, carbon dioxide, dry powder, sand |
| autoignition temperature | 698 ° F. |
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