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Sodium Aldehyde Hyaluronate is a derivative of hyaluronic acid, also known as aldehyde hyaluronic acid sodium.

Catalog 164069

Property	Details
Chemical Name	Sodium aldehyde hyaluronate
CAS Number	Specific CAS number details can vary depending on factors such as the degree of aldehyde modification and the source of hyaluronic acid. There may not be a single, widely – publicized CAS number for all forms of sodium aldehyde hyaluronate, as it can be synthesized with different levels of modification. Precise determination often requires detailed knowledge of the manufacturing process.
Molecular Formula	Hyaluronic acid is a polysaccharide composed of repeating disaccharide units of D – glucuronic acid and N – acetyl – D – glucosamine. When aldehyde groups are introduced and the molecule is in its sodium salt form, the formula becomes more complex. The general structure has the repeating disaccharide backbone with aldehyde – modified groups and sodium counter – ions. If we consider the repeating unit as \((C₁₄H₂₁NO₁₁)\) for unmodified hyaluronic acid, the addition of aldehyde groups ( – CHO) and sodium ions (Na⁺) will change the formula. The approximate formula could be represented as \([(C₁₄H₂₀NO₁₀CHO)Na]ₙ\), where ‘n’ represents the number of repeating units, but this is a simplified approximation and the actual formula depends on the degree and position of aldehyde substitution.
Molecular Weight	The molecular weight of native hyaluronic acid can range from thousands to millions of daltons depending on its degree of polymerization. The introduction of aldehyde groups and sodium ions will affect this. Each aldehyde – modified disaccharide unit with a sodium ion will have an increased molecular weight compared to the unmodified unit. The aldehyde group adds approximately 29 g/mol, and the sodium ion adds 23 g/mol. So, for a given degree of polymerization ‘n’, the molecular weight \(M\) of sodium aldehyde hyaluronate will be higher than that of native hyaluronic acid by \((29 + 23)n\) g/mol plus any additional mass changes due to the specific modification pattern. This can result in a wide range of molecular weights, potentially from a few thousand to very high values depending on the length of the hyaluronic acid chain and the extent of aldehyde modification.
Molecular Structure	The hyaluronic acid backbone has a linear structure with alternating sugar units. Aldehyde groups are introduced, usually by oxidation of hydroxyl groups on the sugar units. This can occur at various positions on the D – glucuronic acid or N – acetyl – D – glucosamine residues. The aldehyde – modified hyaluronic acid then forms a sodium salt, with sodium ions associated with the negatively charged carboxylate groups of the glucuronic acid units and potentially with the aldehyde – related anionic species if any. The aldehyde groups can participate in chemical reactions such as Schiff – base formation with amines, which is important for its applications.
Appearance	Usually appears as a white to off – white powder. The powder may have a fine or granular texture, which can be influenced by the manufacturing process, including drying and milling techniques.
Solubility	Sodium aldehyde hyaluronate is soluble in water. The presence of sodium ions and the hydrophilic nature of the hyaluronic acid backbone contribute to its water – solubility. However, the aldehyde modification can affect the solubility to some extent. In general, it has good solubility in aqueous solutions, which is beneficial for its use in various applications. Solubility in polar organic solvents may be limited, but it may show some solubility in solvents that can interact with the hydrophilic and aldehyde – containing groups, such as lower – molecular – weight alcohols with some water content.
Function in Industry	Biomedical Applications: Tissue Engineering: It can be used to create hydrogels for tissue engineering applications. The aldehyde groups can react with cross – linkers or with other biomolecules containing amine groups, such as proteins or peptides. This allows for the formation of a three – dimensional network with tunable mechanical and biological properties. The hydrogels can be used as scaffolds for cell growth and tissue regeneration. Wound Healing: In wound dressings, sodium aldehyde hyaluronate can promote wound healing. The hyaluronic acid component has natural wound – healing properties, and the aldehyde groups can interact with proteins and cells in the wound area, enhancing cell adhesion and migration. It may also have antibacterial properties due to its ability to react with bacterial cell wall components. Cosmetics: In cosmetics, it can function as a moisturizing and anti – aging agent. The hyaluronic acid part helps in retaining moisture in the skin, and the aldehyde – modified form may have enhanced effects on skin elasticity and firmness. It can also be used in formulations to improve the delivery of other active ingredients to the skin.
Stability	Stable under normal storage conditions, typically at room temperature in a dry and dark place. However, the aldehyde groups are reactive and can be sensitive to factors such as the presence of reducing agents, amines, or high humidity. In the presence of reducing agents, the aldehyde groups can be reduced to alcohols, which can change the properties of the molecule. High humidity can lead to hydrolysis of any labile bonds formed by the aldehyde groups. In formulations, appropriate stabilizers and storage conditions are required to maintain its integrity.
Safety Considerations	In general, sodium aldehyde hyaluronate is considered safe for use in the concentrations typically used in biomedical and cosmetic applications. The hyaluronic acid component has a long – established safety profile. However, the aldehyde modification may introduce some potential risks. Some individuals may be sensitive or allergic to the aldehyde – containing compound. In industrial settings, proper handling procedures should be followed to avoid contact with eyes and skin, and adequate ventilation should be maintained when handling large quantities, especially if there is a risk of inhalation of dust or vapors.

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