Active Pharmaceutical Ingredients

Catalog ID80017098

CAS NO.1716-12-7

Purity 98%

MDL NumberMFCD00800247

EINEC Molecular Formula C10H11NaO2

Molecular Weight 186.1829

Aspect	Details
Chemical Structure	Sodium 4-phenylbutyrate (4-PBA sodium) has the chemical formula C₁₀H₁₃NaO₂. It is a derivative of 4-phenylbutyric acid with a molecular weight of 188.2.
Mechanism of Action	– Acts as a histone deacetylase (HDAC) inhibitor, leading to cell cycle arrest, differentiation, and apoptosis in various tumor cells.<br>- Functions as a chemical chaperone, rescuing the trafficking of misfolded proteins.<br>- Inhibits endoplasmic reticulum (ER) stress, which is implicated in protein folding and cellular stress responses.<br>- Weakly blocks histone deacetylase activity (IC₅₀ = 0.4 mM), resulting in increased histone acetylation.
Clinical Uses	– Used to treat urea cycle disorders by stimulating urinary nitrogen excretion.<br>- Investigated for its potential in cancer therapy due to its antineoplastic and differentiation-inducing properties.<br>- Studied for its effects on ER stress and protein misfolding in various diseases.
Pharmacokinetics	– Undergoes β-oxidation to phenylacetate, a prodrug for phenylacetate.<br>- Stable for 2 years from the date of purchase when stored as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Physical Properties	– Appearance: White to slightly yellow solid.<br>- Solubility: ≥5 mg/mL in water.<br>- Melting Point: 224–226°C (decomposition).
Storage Conditions	Store at room temperature, sealed and protected from moisture.
Side Effects	– Common: Loss of appetite, menstrual changes (delayed/irregular/absent periods).<br>- Serious: Drowsiness, easy bruising/bleeding, fast/pounding heartbeat, mental/mood changes, signs of metabolic imbalance.
Research Applications	– Used in studies related to cancer, ER stress, and protein misfolding.<br>- Investigated for its effects on viral infections, such as ASFV, by inhibiting viral protein synthesis and disrupting viral-induced histone hypoacetylation

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.