Sodium 2-propylpentanoate CAS 1069-66-5
Pharmaceutical Materials 2025-03-03
Sodium 2-propylpentanoate, commonly known as sodium valproate, is a widely recognized broad-spectrum anticonvulsant medication used primarily to manage epilepsy, bipolar disorder, and migraines. Its mechanism involves enhancing GABAergic neurotransmission by inhibiting GABA transaminase and increasing glutamate decarboxylase activity, thereby raising brain GABA levels. Sodium valproate also modulates voltage-gated sodium and calcium channels, contributing to its antiepileptic efficacy. Approved for clinical use since the 1960s, it remains a cornerstone in epilepsy treatment due to its efficacy against various seizure types, including generalized and partial seizures. Despite its therapeutic benefits, its use is associated with adverse effects such as hepatotoxicity, pancreatitis, and teratogenicity, necessitating careful monitoring during treatment.
Usage: A nitrogen-free broad-spectrum antiepileptic drug is used for the treatment and prevention of various types of epilepsy, and has better curative effect on absence seizures and epileptic dyskinesia.
Packaging and Shipping: 25kgs/Drum or as required by buyer.
Storage: Ventilated low temperature drying warehouse;Store separately with food raw materials, oxidants and halogenated hydrocarbons.
| Name | Sodium 2-propylpentanoate |
| CAS No. | 1069-66-5 |
| Molecular Formula | C₈H₁₅NaO₂ |
| Molecular Weight | 166.193 g/mol |
| Appearance | White crystalline powder or granules |
| Melting Point | 300°C |
| Boiling Point | 220°C (760 mmHg) |
| Flash Point | Stable |
| Synthesis | Derived from diethyl malonate |
| Applications | Broad-spectrum antiepileptic drug for seizures, bipolar disorder, migraines |
| Safety | May cause GI disturbances (diarrhea, nausea) or neurological symptoms (dizziness). Store in cool, dry conditions. Use PPE (gloves, goggles, respirator). |
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