Sivelestat sodium tetrahydrate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80020994
CAS NO.201677-61-4
Purity 96%
MDL NumberMFCD01937969
Colecular FormulaC20H21N2NaO7S.4H2O
Molecular Weight528.51
| Category | Information |
|---|---|
| Chemical Properties | Sivelestat sodium tetrahydrate (ONO5046-Na, EI546) is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ value of 44 nM and a Ki value of 200 nM. It has the molecular formula C₂₀H₂₉N₂NaO₁₁S and a molecular weight of 528.51. |
| Physical Properties | It appears as a white to off-white solid. |
| Mechanism of Action | Sivelestat sodium tetrahydrate specifically inhibits neutrophil elastase, a serine protease involved in inflammatory processes. It does not inhibit other serine proteases such as trypsin, thrombin, or plasmin even at high concentrations (100 μM). |
| Biological Activity | – In Vitro: Exhibits IC₅₀ values of 44 nM, 36 nM, 19 nM, 37 nM, and 49 nM for human, rabbit, rat, hamster, and mouse neutrophil elastase, respectively.<br>- In Vivo: Suppresses lung hemorrhage in hamsters and reduces skin capillary permeability in guinea pigs induced by human neutrophil elastase. |
| Clinical Potential | – Acute Lung Injury/ARDS: Has potential for treating acute lung injury and acute respiratory distress syndrome (ARDS).<br>- COVID-19: Studied for its potential use in managing COVID-19-related acute lung injury and disseminated intravascular coagulation. |
| Storage Conditions | – Powder: Store at -20°C for up to 3 years.<br>- In Solvent: Store at -80°C for up to 1 year. |
| Solubility | – DMSO: Soluble up to 225 mg/mL.<br>- Ethanol: Soluble up to 8 mg/mL.<br>- Water: Insoluble. |
| Research Applications | – Inflammation and Immunity: Useful for studying inflammatory processes and neutrophil-mediated tissue damage.<br>- Drug Development: Serves as a reference compound for developing new elastase inhibitors. |
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