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Silanized Hyaluronate is a derivative of hyaluronic acid, also known as silane-modified hyaluronic acid.

CAS 135507-00-5 Catalog 164067

Property	Details
Chemical Name	Silanized hyaluronate
CAS Number	Specific CAS number information may be scarce as it can vary depending on the type of silane used for modification and the degree of substitution on the hyaluronic acid backbone. Precise determination often requires detailed knowledge of the synthesis process and the exact structure of the silanized product.
Molecular Formula	Hyaluronic acid consists of repeating disaccharide units of D – glucuronic acid and N – acetyl – D – glucosamine, with a general formula for the repeating unit being \((C_{14}H_{21}NO_{11})\). When silanized, silane groups with the general formula \(R_{n}Si(OR’)_{4 – n}\) (where \(R\) and \(R’\) are various organic groups) react with the hydroxyl or carboxyl groups on the hyaluronic acid chains. If we assume an average degree of substitution \(x\) of silane groups per repeating unit, a simplified formula could be \([(C_{14}H_{21 – a}NO_{11 – b})(SiR_{n}(OR’)_{4 – n})_{x}]_{m}\), where \(a\) and \(b\) are the number of atoms removed from the hyaluronic acid unit during the reaction with silane, and \(m\) is the number of repeating units in the hyaluronic acid chain. However, this is a highly simplified representation, and the actual formula depends on many factors such as the type of silane and the reaction conditions.
Molecular Structure	The basic hyaluronic acid linear chain, composed of the repeating disaccharide units, serves as the backbone. Silane groups are attached to the hyaluronic acid chains. The attachment can occur through covalent bonds formed between the reactive groups on the silane (such as alkoxysilyl groups) and the hydroxyl or carboxyl groups on the sugar units of hyaluronic acid. The silane modification can change the surface properties of the hyaluronic acid. For example, if the silane has long – chain alkyl groups (\(R\)), it can introduce hydrophobic regions on the otherwise hydrophilic hyaluronic acid molecule.
Appearance	Usually appears as a white to off – white powder, similar to native hyaluronic acid in its solid form. The powder texture can be fine or slightly coarser depending on the synthesis and processing methods. In solution, the silanized hyaluronic acid may behave differently from native hyaluronic acid, potentially showing altered solubility and aggregation behavior.
Solubility	The solubility of silanized hyaluronic acid depends on the type and degree of silane modification. Native hyaluronic acid is highly soluble in water due to its hydrophilic nature. However, the introduction of hydrophobic silane groups can decrease its water solubility. If the degree of silanization is low, it may still show some solubility in water or in aqueous solutions with added surfactants that can help solubilize the hydrophobic regions. In organic solvents, its solubility may increase compared to native hyaluronic acid, especially in non – polar or moderately polar organic solvents, depending on the nature of the silane groups. For example, if the silane has alkyl groups, it may be more soluble in solvents like toluene or chloroform.
Function in Industry	Biomedical Applications: Cell Culture Substrates: Silanized hyaluronic acid can be used to modify the surface of cell culture dishes. The silane groups can be designed to interact with the cell culture surface, providing better adhesion and spreading of cells. The hyaluronic acid component also has natural cell – friendly properties, promoting cell growth and viability. Drug Delivery: It can be used as a component in drug delivery systems. The hydrophobic silane groups can be used to encapsulate hydrophobic drugs, while the hyaluronic acid part can provide biocompatibility and potentially target – specific delivery. For example, if the hyaluronic acid is modified to target specific cell surface receptors, the drug – loaded silanized hyaluronic acid can be directed to specific cells in the body. Tissue Engineering: In tissue engineering, silanized hyaluronic acid can be used to create scaffolds. The silane modification can improve the mechanical properties of the scaffolds by allowing for better cross – linking or interaction with other scaffold materials. The hyaluronic acid can enhance cell – matrix interactions, promoting tissue regeneration. Cosmetics: In cosmetics, it can be used to improve the stability and performance of products. The silane modification can make the hyaluronic acid more resistant to degradation in the presence of certain ingredients in cosmetic formulations. It can also provide unique texture and feel to skincare products, such as creating a smoother and more long – lasting moisturizing effect.
Stability	Stability is influenced by factors such as temperature, humidity, and the presence of reactive chemicals. The silane – hyaluronic acid bonds can be sensitive to hydrolysis, especially in the presence of water and under acidic or basic conditions. High temperatures can also accelerate degradation reactions. In formulations, proper storage conditions, such as storing in a dry and cool place, are important. Additionally, the choice of silane and the degree of substitution can affect stability. For example, more stable silane – hyaluronic acid linkages can be achieved with certain types of silanes and reaction conditions, which can help in maintaining the integrity of the product over time.
Safety Considerations	In general, silanized hyaluronic acid is considered safe for use in biomedical and cosmetic applications, given the biocompatibility of hyaluronic acid. However, the silane modification may introduce some potential risks. Some individuals may be sensitive or allergic to the silane – containing compound, especially if the silane has reactive or allergenic groups. In industrial settings, proper handling procedures should be followed to avoid contact with eyes and skin. When handling large quantities, adequate ventilation should be maintained to prevent inhalation of dust (if in powder form) or vapors that may be released during processing.

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