Selexipag CAS NO.:475086-01-2
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Category：Pharmaceutical Materials | Brand：MT
Introduction
Catalog ID:94602
CAS NO.:475086-01-2
MDL Number:MFCD10567093
Molecular Weight:496.62
Selexipag, also known as NS-304, is an orally available and long-acting prostacyclin receptor agonist prodrug. It belongs to the class of pharmaceutical intermediates and has been approved by the US FDA for the treatment of pulmonary arterial hypertension (PAH) in adult patients. Selexipag acts by relaxing the smooth muscle of the blood vessels, thereby expanding the vessels and reducing pulmonary arterial pressure. It is a promising therapeutic option for patients with this chronic and progressive lung disease.
| Property | Details |
|---|---|
| CAS Number | 475086-01-2 |
| Chemical Name | Selexipag |
| Synonyms | NS-304, ACT-293987, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide |
| Molecular Formula | C26H32N4O4S |
| Molecular Weight | 496.622 g/mol |
| Appearance | Solid, typically pale yellow |
| Density | 1.210 ± 0.06 g/cm³ (predicted) |
| Melting Point | 134-138 °C |
| Solubility | Soluble in DMSO (slightly), methanol (slightly) |
| LogP | 4.56 |
| Refractive Index | 1.579 |
| PSA | 113.36000 Ų |
| pKa | 3.82 ± 0.40 (predicted) |
| Uses | Pharmaceutical intermediate, specifically for the treatment of pulmonary arterial hypertension |
| Storage Conditions | -20 °C frozen |
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