Active Pharmaceutical Ingredients

Secnidazole is an anti-infective drug of the nitroimidazole class. Its structure and pharmacological effects are similar to metronidazole. It has the effects of anti-trichomonas and anti-amoeba protozoa.

Molecular Formula:C7H11N3O3

Molecular Weight:185.180

CAS No.: 3366-95-8

Description

Secnidazole is a almost white or slightly yellowish crystalline powder. It is freely soluble in ethanol, soluble in chloroform, sparingly in water or enthyl ether, freely soluble in dilute acid.

Application

Secnidazole is an anti-infective drug of the nitroimidazole class. Its structure and pharmacological effects are similar to metronidazole. It is a white to off-white or slightly yellow crystalline powder at room temperature. It is odorless, bitter, and has the effects of anti-trichomonas and anti-amoeba protozoa. By acting on the growth period of protozoa or anaerobic bacteria, it destroys the DNA chain or inhibits DNA synthesis, resulting in the death of protozoa and anaerobic bacteria.

Clinically, secnidazole can be used to treat urethritis, vaginitis, and male prostatitis caused by Trichomonas vaginalis, various acute and chronic hepato-intestinal amebiasis, as well as giardiasis and anaerobic infection of various parts of the human body.

Packing

25Kg per drum

Storage：

Preserve in tight containers in a dry place.

Shelf Life :

36 months from date of production when stored in good condition.

Minimum Order

One package

Secnidazole Introduction

Item	Details
Generic Name	Secnidazole
CAS Number	3366 – 95 – 8
Trade Names	For example, Flagyl (in some formulations), although it’s not as commonly known by trade names compared to some drugs.
Classification	Nitroimidazole – class antibacterial and antiprotozoal agent
Chemical Structure	Its chemical name is 1 – (2 – hydroxyethyl)-2 – methyl – 5 – nitro – 1H – imidazole. The molecular formula is C₇H₁₀N₄O₃, with a molecular weight of 198.18. The nitroimidazole ring is the key structural feature that contributes to its biological activity. This structure allows it to interact with the DNA of target microorganisms.
Pharmacological Action	Secnidazole works by being reduced within the anaerobic bacteria or protozoa. The reduced form then binds to DNA, causing strand breakage and inhibiting DNA synthesis and repair. This leads to the death of the microorganism. It has a high activity against anaerobic bacteria, including Bacteroides fragilis, Clostridium difficile, and protozoa such as Trichomonas vaginalis and Entamoeba histolytica.
Clinical Applications	1. Anaerobic Bacterial Infections: – Intra – abdominal infections, including peritonitis and abscesses caused by anaerobic bacteria. – Pelvic inflammatory disease, especially when anaerobic bacteria are involved. – Oral infections like periodontitis and dental abscesses, as many oral pathogens are anaerobic. 2. Protozoal Infections: – Trichomoniasis, which is a common sexually – transmitted disease caused by Trichomonas vaginalis. A single – dose treatment is often effective. – Amoebiasis, for the treatment of intestinal and extra – intestinal amoebic infections caused by Entamoeba histolytica.
Dosage and Administration	For Anaerobic Bacterial Infections: – Adults: Usually, a single – dose treatment of 2 g is given orally for uncomplicated infections. For more severe or complicated cases, the dose may be divided and given over a few days, for example, 1 g twice daily for 3 days. For Trichomoniasis: – A single – dose of 2 g is administered orally for both men and women. For Amoebiasis: – For intestinal amoebiasis, adults may take 1.5 g once daily for 3 days. For extra – intestinal amoebiasis, the treatment may be more prolonged, such as 1 g twice daily for 5 – 10 days. It is usually taken orally, and it can be taken with or without food, but taking it with food may reduce gastrointestinal side effects.
Adverse Reactions	1. Gastrointestinal Effects: Nausea, vomiting, anorexia, and a metallic taste in the mouth are relatively common. Diarrhea and abdominal pain may also occur. 2. Neurological Effects: Headache, dizziness, and in rare cases, seizures or peripheral neuropathy may be experienced, especially with long – term or high – dose use. 3. Allergic Reactions: Rashes, itching, and in severe cases, anaphylactic reactions can occur, although they are not very common. 4. Hematological Effects: Rarely, it may cause transient decreases in white blood cell counts or other blood cell abnormalities. 5. Other Effects: Darkening of the urine may be observed, which is usually harmless and due to the drug’s metabolites.
Drug Interactions	1. With Alcohol: Consumption of alcohol during secnidazole treatment can lead to a disulfiram – like reaction, causing flushing, headache, nausea, and vomiting. So, alcohol should be avoided during treatment and for a few days after stopping the drug. 2. With Anticoagulants: It may enhance the anticoagulant effect of warfarin and other coumarin – type anticoagulants, increasing the risk of bleeding. Close monitoring of prothrombin time is required when used together. 3. With CYP450 – related Drugs: Since secnidazole is metabolized by the liver’s cytochrome P450 enzyme system, it may interact with drugs that are substrates or inhibitors of this system. For example, drugs that inhibit CYP450 may increase secnidazole levels, while drugs that induce CYP450 may decrease its levels.
Special Population Considerations	1. Pregnant Women: Use during pregnancy is generally not recommended, especially in the first trimester, as there may be potential risks to the fetus. However, in some cases where the benefits outweigh the risks, it may be used under strict medical supervision. 2. Breastfeeding Women: It is excreted in breast milk, so breastfeeding should be discontinued during treatment or the mother should pump and discard the milk during this time. 3. Patients with Liver Impairment: The drug may accumulate in patients with significant liver impairment, so dosage adjustment may be necessary. 4. Elderly Patients: Elderly patients may be more sensitive to the drug’s side effects, and careful monitoring is required, especially for neurological and gastrointestinal effects.
History and Development	Secnidazole has been developed as an alternative to other nitroimidazole drugs like metronidazole. It offers the advantage of longer – acting properties in some cases, allowing for more convenient dosing regimens, such as single – dose treatments for certain infections. It has been used clinically for several decades and is widely available in many countries for the treatment of anaerobic bacterial and protozoal infections.

 

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