Active Pharmaceutical Ingredients

Catalog ID80020990

CAS NO.515-03-7

Purity 98%

MDL NumberMFCD00869558

EINEC208-194-0

Molecular formula C20H36O2

Molecular weight 308.4986

Melting point: 95~100℃

Boiling point: 218~220℃ (19 mmHg)

Category	Information
Chemical Properties	Sclareol is a diterpene alcohol with the molecular formula C₂₀H₃₆O₂ and a molecular weight of 316.5. It is a natural compound isolated primarily from the herb Salvia sclarea (clary sage).
Physical Properties	It appears as a white to off-white crystalline solid. It has low water solubility but is lipophilic, making it suitable for encapsulation in liposomes and nanoparticles.
Natural Sources	Sclareol is predominantly found in the essential oil of Salvia sclarea (clary sage), where it constitutes 11.5-15.7% of the oil. It is also present in other plants such as Cistus creticus, Nicotiana glutinosa, and Cleome spinosa.
Biological Activities	– Anti-inflammatory Effects: Sclareol inhibits NF-κB and MAPK signaling pathways, reducing inflammation in various models.<br>- Antitumor Activity: It has been shown to enhance the efficacy of chemotherapeutic agents like doxorubicin and induce apoptosis in cancer cells.<br>- Antimicrobial Effects: Exhibits antibacterial and antifungal properties.<br>- Anti-diabetic and Anti-hypertensive: Potential applications in managing diabetes and hypertension.
Applications	– Pharmaceuticals: Used in the synthesis of Ambrox (ambroxide), a fragrance compound.<br>- Cosmetics and Food: Utilized as a natural flavor and fragrance ingredient.<br>- Medicinal Uses: Investigated for its potential in treating various diseases, including cancer, inflammation, and COVID-19.
Delivery Systems	Due to its low water solubility, sclareol is often encapsulated in liposomes, lipid nanoparticles (LNPs), and nanostructured lipid carriers (NLCs) to enhance its bioavailability and therapeutic efficacy.
Research Potential	Sclareol is being explored as a potential candidate for treating COVID-19 and Parkinson’s disease, highlighting its broad-spectrum biological activities

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