Sarolaner
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms PF6450567 1-[6-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3′-azetidine]-1′-yl]-2-methylsulfonylethanone (S)-1-(5′-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’H-spiro[azetidine-3,1′-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone
Catalog ID101255
CAS NO.1398609-39-6
Purity 97%
MDL NumberMFCD28963963
EINEColecular FormulaC23H18Cl2F4N2O5S
Molecular Weight581.368
| Category | Content |
|---|---|
| Generic Name | Sarolaner |
| Brand Name | Simparica, Simparica Trio |
| Chemical Formula | C23H18Cl2F4N2O5S |
| Mechanism of Action | Sarolaner is an isoxazoline that inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor at the neuromuscular junction in insects, leading to uncontrolled neuromuscular activity and death in insects or acarines. |
| Indications | – Treatment and prevention of flea infestations (Ctenocephalides felis and Ctenocephalides canis) in dogs.<br>- Treatment and control of tick infestations (e.g., Amblyomma spp., Dermacentor spp., Ixodes spp., Rhipicephalus spp.).<br>- Prevention of heartworm disease caused by Dirofilaria immitis.<br>- Treatment and control of roundworm and hookworm infections.<br>- Can be used as part of a treatment strategy for Flea Allergy Dermatitis (FAD). |
| Dosage Forms | Chewable tablets |
| Administration | Oral use in dogs, once a month. Can be given with or without food. |
| Pharmacokinetics | Sarolaner is rapidly absorbed after oral administration and has a long-lasting effect. |
| Side Effects | Generally well-tolerated in dogs. Possible side effects include vomiting, diarrhea, and lethargy. |
| Developer | Zoetis |
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