Salmeterol
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80019728
CAS NO.89365-50-4
Purity 99%
MDL NumberMFCD00867037
Molecular FormulaC25H37NO4
Molecular Weight415.5656
Melting point: 75.5~76.5°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₂₅H₃₇NO₄<br>- Molecular Weight: 419.57 g/mol |
| Physical Properties | – Appearance: White to off-white solid |
| Mechanism of Action | – Salmeterol is a long-acting beta-2 adrenergic receptor agonist that binds to both the active and exo sites of the beta-2 adrenergic receptor.<br>- It stimulates adenylyl cyclase, converting ATP to cAMP, which activates protein kinase A and inhibits myosin light chain kinase, leading to bronchodilation.<br>- It also inhibits the release of mast cell mediators such as histamine, leukotrienes, and prostaglandins, reducing inflammation. |
| Clinical Uses | – Asthma: Used in combination with inhaled corticosteroids for maintenance and prevention of asthma attacks.<br>- Chronic Obstructive Pulmonary Disease (COPD): Used as monotherapy for maintenance treatment.<br>- Exercise-Induced Bronchospasm (EIB): Prevents exercise-induced bronchospasm. |
| Dosage Forms | – Inhalation powder and aerosol.<br>- Typically administered twice daily. |
| Adverse Effects | – Common: Headache, dizziness, tremor, palpitations.<br>- Rare: Hypokalemia, hypoglycemia.<br>- Caution: Increased risk of mortality with monotherapy in asthma patients. |
| Storage Conditions | Store at room temperature, protect from moisture. |
| Special Notes | – Contraindications: Monotherapy is contraindicated for asthma due to increased mortality risk.<br>- Drug Interactions: Use with caution in patients with severe liver dysfunction.<br>- Potent CYP3A4 Inhibitors: Avoid concurrent use with potent CYP3A4 inhibitors (e.g., ritonavir, itraconazole) due to increased risk of adverse effects. |
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