Pharmaceutical Materials

Molecular Formula: C11H9NO3 Molecular Weight: 203.19 CAS Registry Number: 161596-47-0

Name: (S)-(+)-N-(2,3-Epoxypropyl)phthalimide

CAS: 161596-47-0

Appearance: white to off-white powder

Purity: ≥99%

Capacity: 100mt/year

Min.package: 1gram

Application: Rivaroxaban intermediate

Standard: enterprise export

(S) N-glycidyl phthalimide, commonly referred to as (S) – N-PiP ((S) – N-phenylpyrrole-2-carboxamide).

nature:

(S) N-glycidyl phthalimide is an organic compound. It is a colorless to light yellow crystal that is soluble in common organic solvents such as dimethyl sulfoxide and dichloromethane.

Purpose:

(S) N-glycidyl phthalimide is widely used in chiral organic synthesis as a precursor for chiral catalysts or ligands. It can be used for asymmetric synthesis reactions, such as asymmetric addition and asymmetric dehydration.

Manufacturing method:

(S) The preparation of N-glycidol phthalimide is usually achieved by first synthesizing (S) – N-glycidol ((S) – N-proline) and then reacting it with phthalimide. The specific preparation method can refer to relevant organic synthesis literature.

Security information:

(S) There are currently few reports on the safety information of N-glycidyl phthalimide, but as an organic compound, the following safety measures should generally be taken:

-Avoid contact with skin, eyes, or respiratory tract, and wear appropriate protective gloves, glasses, and masks.

-During the operation, it is necessary to prevent the generation of dust, smoke, or gas and maintain well ventilated laboratory conditions.

-Store in a dry and cool place, away from sources of fire and oxidants.

-Follow proper handling and disposal procedures to avoid harm to the environment.

Name	(S)-(+)-Glycidyl Phthalimide
Synonyms	Rivaroxaban Impurity 39 (S)-Glycidyl Phthalimide (S)-GLYCIDYL PHTHALIMIDE (S)-N-Glycidylphthalimide Diethyl (3-pyridyl) borane N-(S)-Glycidylphthalimide (S)-(+)-Glycidyl Phthalimide (S)-(+)-GLYCIDYL PHTHALIMIDE (S)-(+)-Glycidyl phthalimide (S)-(+)-N-(2,3-Epoxypropyl)phthalimide (S)-2-oxiranylmethyl-isoindole-1,3-dione (S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE 2-[[(2S)-oxiran-2-yl]methyl]isoindole-1,3-dione 2-((2S)-oxiranylmethyl)-1H-isoindole-1,3(2H)-dione 2-((2S)-OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE 2-[(2S)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione 1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2-oxiranylmethyl]-
CAS	161596-47-0
EINECS	1308068-626-2
InChI	InChI=1/C11H9NO3/c13-10-8-3-1-2-4-9(8)11(14)12(10)5-7-6-15-7/h1-4,7H,5-6H2/t7-/m0/s1

Molecular Formula	C11H9NO3
Molar Mass	203.19
Density	1.446±0.06 g/cm3(Predicted)
Melting Point	102 °C
Boling Point	347.4±15.0 °C(Predicted)
Flash Point	163.9°C
Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
Vapor Presure	0.001-2.17Pa at 25-90.25℃
Appearance	White powder
Color	White
pKa	-2.24±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Sensitive	Easily absorbing moisture
Refractive Index	10 ° (C=2.2, CHCl3)

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