(S)-10-Hydroxycamptothecin CAS: 19685-09-7

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Introduction

CAS: 19685-09-7

Purity: ≥99%

Capacity: 200mt/year MOQ: 217g

Application: Organic Intermediate

Standard: Enterprise export

Manufacturer: Jinan Finer Chemical Co., Ltd

Synonyms: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 10-Hydroxycamptothecin 10-Hydroxycamptothecine Molecular Formula: C20H16N2O5

Molecular Weight: 364.35

CAS Registry Number: 19685-09-7

Density: 1.60

Melting point: 265-270 ºC

(S)-10-Hydroxycamptothecin, with the CAS number 19685-09-7, is a naturally occurring alkaloid derived from the seeds or root bark of the Camptotheca acuminata tree. This compound has gained significant attention due to its potent inhibitory activity against topoisomerase I, an enzyme crucial for DNA replication and repair. (S)-10-Hydroxycamptothecin exists as a yellow to orange crystalline powder and is primarily used in the development of anticancer drugs. Its mechanism of action involves stabilizing the topoisomerase I-DNA covalent complex, leading to DNA damage and ultimately cell death. This compound holds promise for the treatment of various cancers, making it a valuable addition to the field of oncology.

Property Category Details
Chemical Name (S)-10-Hydroxycamptothecin
CAS Number 19685-09-7
Molecular Formula C20H16N2O5
Molecular Weight 364.35 g/mol
Physical Properties
– Appearance Yellow to orange crystalline powder
– Density 1.6 ± 0.1 g/cm³
– Melting Point 265-270 °C
– Boiling Point 820.7 ± 65.0 °C at 760 mmHg
– Flash Point 450.1 ± 34.3 °C
– Refractive Index 1.777
Chemical Properties
– Solubility Soluble in organic solvents
– pH N/A (typically used in pharmaceutical formulations at physiologically compatible pH)
– Stability Stable under recommended storage conditions (-20 °C)
– Functional Group Hydroxy, quinoline, pyran ring
– Application Anticancer drug development, topoisomerase I inhibitor

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