(S)-10-Hydroxycamptothecin CAS: 19685-09-7
Chemical Intermediates 2025-03-02
CAS: 19685-09-7
Purity: ≥99%
Capacity: 200mt/year MOQ: 217g
Application: Organic Intermediate
Standard: Enterprise export
Manufacturer: Jinan Finer Chemical Co., Ltd
Synonyms: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 10-Hydroxycamptothecin 10-Hydroxycamptothecine Molecular Formula: C20H16N2O5
Molecular Weight: 364.35
CAS Registry Number: 19685-09-7
Density: 1.60
Melting point: 265-270 ºC
(S)-10-Hydroxycamptothecin, with the CAS number 19685-09-7, is a naturally occurring alkaloid derived from the seeds or root bark of the Camptotheca acuminata tree. This compound has gained significant attention due to its potent inhibitory activity against topoisomerase I, an enzyme crucial for DNA replication and repair. (S)-10-Hydroxycamptothecin exists as a yellow to orange crystalline powder and is primarily used in the development of anticancer drugs. Its mechanism of action involves stabilizing the topoisomerase I-DNA covalent complex, leading to DNA damage and ultimately cell death. This compound holds promise for the treatment of various cancers, making it a valuable addition to the field of oncology.
| Property Category | Details |
|---|---|
| Chemical Name | (S)-10-Hydroxycamptothecin |
| CAS Number | 19685-09-7 |
| Molecular Formula | C20H16N2O5 |
| Molecular Weight | 364.35 g/mol |
| Physical Properties | |
| – Appearance | Yellow to orange crystalline powder |
| – Density | 1.6 ± 0.1 g/cm³ |
| – Melting Point | 265-270 °C |
| – Boiling Point | 820.7 ± 65.0 °C at 760 mmHg |
| – Flash Point | 450.1 ± 34.3 °C |
| – Refractive Index | 1.777 |
| Chemical Properties | |
| – Solubility | Soluble in organic solvents |
| – pH | N/A (typically used in pharmaceutical formulations at physiologically compatible pH) |
| – Stability | Stable under recommended storage conditions (-20 °C) |
| – Functional Group | Hydroxy, quinoline, pyran ring |
| – Application | Anticancer drug development, topoisomerase I inhibitor |
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