(S)-1-Boc-3-hydroxypiperidine CAS: 143900-44-1
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS Number: 143900-44-1
Molecular Formula: C10H19NO3
Molecular Weight: 201.26 g/mol
Appearance: White to brownish powder
Melting Point: 34-40°C
Boiling Point: 292.3°C (predicted) Usage: It is an important chiral intermediate in the synthesis of ibrutinib.
| Property | Details |
|---|---|
| Chemical Name | (S)-1-Boc-3-hydroxypiperidine |
| CAS Number | 143900-44-1 |
| Synonyms | (S)-3-Hydroxy-1-(tert-butoxycarbonyl)piperidine; (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine; (S)-(-)-1-Boc-3-piperidinol; (S)-(-)-3-Hydroxy-1-Boc-piperidine |
| Molecular Formula | C10H19NO4 |
| Molecular Weight | 217.26 g/mol |
| Chemical Structure | A chiral piperidine derivative with a Boc (tert-butoxycarbonyl) group at the 1-position and a hydroxyl group at the 3-position. |
| Physical State | Liquid or solid (depending on temperature and conditions) |
| Appearance | Colorless to pale yellow |
| Density | ~1.1 g/cm³ (approx.) |
| Melting Point | ~60-65°C (lit.) |
| Boiling Point | >200°C (decomposition) |
| Solubility | Soluble in organic solvents such as DMSO, ethanol, and acetonitrile. Insoluble in water. |
| Optical Rotation | [α]D20 -46° to -52° (c = 1. CHCl3) |
| Stability | Stable under normal conditions. Avoid exposure to heat and incompatible materials. |
| Applications | Used as a chiral building block in organic synthesis, particularly in the preparation of pharmaceuticals and other biologically active compounds. It serves as an intermediate in the synthesis of protected amines and amino acids. |
| Storage Conditions | Store in a cool, dry place, away from direct sunlight and incompatible materials. Keep the container tightly closed. |
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