Rucaparib phosphate
We are a manufacturer based in China, specializing in high-quality Rucaparib phosphate for industrial clients worldwide. Technical support and custom formulation available.
Category：Active Pharmaceutical Ingredients | Brand：MT
Introduction
English Synonyms AG-014699 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate
Catalog ID100236
CAS NO.459868-92-9
Purity 99%
MDL NumberMFCD17010269
EINEC Molecular FormulaC19H21FN3O5P
Molecular Weight421.359
Appearance:Light yellow powder
| Category | Content |
|---|---|
| Generic Name | Rucaparib Phosphate (AG-014699 Phosphate) |
| Chemical Formula | C19H21FN3O5P.H3PO4 |
| Mechanism of Action | Rucaparib phosphate is an orally active inhibitor of PARP proteins (PARP-1, PARP-2, and PARP-3) with a Ki of 1.4 nM for PARP-1. It inhibits DNA repair processes, leading to cancer cell death. |
| Indications | Used for the treatment of ovarian cancer, prostate cancer, and other solid tumors with BRCA mutations. It is also being investigated for use in combination with other therapies. |
| Pharmacokinetics | – Detectable in plasma within 30 minutes after intraperitoneal injection and up to 4 hours after oral administration.<br>- Shows significant antitumor activity in various animal models. |
| Clinical Trials | – Phase 3 clinical trials are ongoing for various cancers.<br>- Studies show enhanced antitumor effects when combined with temozolomide. |
| Storage | Store at 4°C, sealed and protected from moisture. |
| Solubility | – Soluble in DMSO (≥33 mg/mL) and water (5 mg/mL with sonication) .<br>- Insoluble in ethanol. |
| Appearance | Light yellow to yellow powder. |
| CAS Number | 459868-92-9 |
| Molecular Weight | 421.36 |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
Inquiry
We'll reply within 24 hours
