Rucaparib phosphate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms AG-014699 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate
Catalog ID100236
CAS NO.459868-92-9
Purity 99%
MDL NumberMFCD17010269
EINEC Molecular FormulaC19H21FN3O5P
Molecular Weight421.359
Appearance:Light yellow powder
| Category | Content |
|---|---|
| Generic Name | Rucaparib Phosphate (AG-014699 Phosphate) |
| Chemical Formula | C19H21FN3O5P.H3PO4 |
| Mechanism of Action | Rucaparib phosphate is an orally active inhibitor of PARP proteins (PARP-1, PARP-2, and PARP-3) with a Ki of 1.4 nM for PARP-1. It inhibits DNA repair processes, leading to cancer cell death. |
| Indications | Used for the treatment of ovarian cancer, prostate cancer, and other solid tumors with BRCA mutations. It is also being investigated for use in combination with other therapies. |
| Pharmacokinetics | – Detectable in plasma within 30 minutes after intraperitoneal injection and up to 4 hours after oral administration.<br>- Shows significant antitumor activity in various animal models. |
| Clinical Trials | – Phase 3 clinical trials are ongoing for various cancers.<br>- Studies show enhanced antitumor effects when combined with temozolomide. |
| Storage | Store at 4°C, sealed and protected from moisture. |
| Solubility | – Soluble in DMSO (≥33 mg/mL) and water (5 mg/mL with sonication) .<br>- Insoluble in ethanol. |
| Appearance | Light yellow to yellow powder. |
| CAS Number | 459868-92-9 |
| Molecular Weight | 421.36 |
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