Rubitecan
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80021076
CAS NO.91421-42-0
Purity 98%
MDL NumberMFCD06656294
Molecular FormulaC20H15N3O6
Molecular Weight393.3496
Melting point: 182~186°C
| Category | Information |
|---|---|
| Chemical Properties | Rubitecan (9-Nitrocamptothecin) is a semisynthetic derivative of camptothecin. It has the molecular formula C₂₀H₁₅N₃O₆ with a molecular weight of 393.35. It is a yellow crystalline powder. |
| Physical Properties | It has a melting point of 182-186°C, a density of 1.63 g/cm³, and is insoluble in water. |
| Mechanism of Action | Rubitecan is an inhibitor of topoisomerase I, a nuclear enzyme that controls DNA topology. It stabilizes the topoisomerase I-DNA covalent complex, preventing DNA repair and leading to cell death. |
| Antitumor Activity | It has shown broad antitumor activity, particularly in pancreatic cancer and ovarian cancer. In vitro studies have demonstrated cytotoxicity against various cell lines, with IC₅₀ values ranging from 0.112 to 0.479 μM. |
| Clinical Trials | Clinical trials have explored its use in treating various cancers, including bladder cancer, esophageal cancer, gastric cancer, and pancreatic cancer. |
| Storage Conditions | As a powder, it should be stored at -20°C for up to 3 years or at 4°C for up to 2 years. When dissolved in a solvent, it is stable for 2 years at -80°C and 1 year at -20°C. |
| Applications | Rubitecan is primarily used in cancer research and as a potential therapeutic agent for refractory cancers. It is also being explored as a payload for antibody-drug conjugates (ADCs) due to its potent antitumor activity. |
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