Ropivacaine HCl
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017996
CAS NO.132112-35-7
Purity 98%
MDL NumberMFCD00946578
Molecular Formula C17H26N2O.HCl.H2O
Molecular Weight 328.8774
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C17H26ClN3O2<br> Molecular weight: 341.88 g/mol |
| Physical Properties | Appearance: White to off-white crystalline powder<br> Melting point: 146.5–148°C |
| Mechanism of Action | Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium ion influx in nerve fibers, blocking the propagation of action potentials. It is less lipophilic than bupivacaine, selectively acting on nociceptive A, B, and C fibers over motor fibers, resulting in reduced motor blockade. |
| Pharmacokinetics | Absorption: Rapid and complete from the epidural space.<br> Distribution: 94% protein-bound, primarily to α1-acid glycoprotein.<br> Metabolism: Extensively metabolized in the liver by CYP1A2 and CYP3A4.<br> Excretion: Primarily excreted in urine, with a terminal half-life of 1.8–4.2 hours. |
| Therapeutic Uses | Anesthesia: Used for various surgical procedures, including lumbar surgery, cesarean sections, and thoracic surgeries.<br> Postoperative Pain Management: Effective in reducing postoperative pain and opioid requirements.<br> Labor Analgesia: Provides effective pain relief with stable hemodynamics. |
| Safety Information | Side Effects: May cause dizziness, headache, and gastrointestinal discomfort.<br> Toxicity: Lower potential for cardiotoxicity and central nervous system toxicity compared to bupivacaine.<br> Contraindications: Avoid in patients with hypersensitivity to ropivacaine. |
| Storage Conditions | Store at room temperature, protect from light and moisture |
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