Ritonavir
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS NO.: 155213-67-5
Molecular formula: C4H5NOS
Molecular weight: 115.15
Standard: enterprise standard
Content: ≥98.0%
Packaging: 25KG/barrel
Introduction to Ritonavir
| Attribute | Details |
|---|---|
| Chemical Name | Ritonavir (ABT 538) |
| Brand Name | Norvir |
| Mechanism of Action | – HIV Protease Inhibitor: Ritonavir inhibits HIV-1 and HIV-2 proteases, preventing the maturation of viral particles.<br>- CYP3A4 Inhibitor: It also inhibits the cytochrome P450 3A4 enzyme, which boosts the efficacy of other antiviral drugs. |
| Clinical Uses | – HIV/AIDS Treatment: Used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART).<br>- COVID-19 Treatment: Combined with nirmatrelvir (as Paxlovid) to inhibit SARS-CoV-2 main protease (Mpro) and reduce viral replication.<br>- Hepatitis C: Used in combination with other drugs for treating hepatitis C virus (HCV) genotype 4. |
| Pharmacokinetics | – Protein Binding: 98–99%.<br>- Metabolism: Primarily via liver CYP3A4.<br>- Half-Life: 3–4 hours.<br>- Excretion: Mostly fecal. |
| Adverse Effects | – Common: Nausea, vomiting, loss of appetite, diarrhea.<br>- Serious: Liver complications, pancreatitis, allergic reactions, arrhythmias. |
| Interactions | – Drug Interactions: Significant interactions with drugs metabolized by CYP3A4, such as amiodarone and simvastatin.<br>- Booster Role: Enhances the efficacy of other protease inhibitors by inhibiting their metabolism. |
| Development and Approval | – Patented: 1989.<br>- FDA Approval: March 1, 1996.<br>- Generic Availability: Approved in the US in 2020.<br>- WHO Essential Medicines List: Yes. |
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