Risedronic acid monohydrate CAS NO.105462-24-6
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017483
CAS NO.105462-24-6
Purity 97%
MDL NumberMFCD09025818
EINEC Molecular FormulaC7H11NO7P2.H2O
Molecular Weight301.1275
Melting point: 203~205°C
| Aspect | Details |
|---|---|
| Chemical Structure | Molecular Formula: C7H11NO7P2<br>Molecular Weight: 283.11 |
| Synonyms | – Risedronic acid<br>- Risedronate<br>- (1-Hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid monohydrate |
| Mechanism of Action | Risedronic acid is a third-generation bisphosphonate that inhibits osteoclast-mediated bone resorption. It binds to hydroxyapatite crystals in bone and inhibits the enzyme farnesyl diphosphate synthase (FPPS), crucial for osteoclast function. |
| Indications | – Treatment and prevention of osteoporosis in postmenopausal women.<br>- Treatment of Paget’s disease of bone.<br>- Treatment of osteoporosis in men. |
| Pharmacokinetics | – Absorbed orally, with peak plasma concentrations reached within 1 hour.<br>- Metabolized in the liver and excreted in urine.<br>- Half-life is approximately 13 hours. |
| Adverse Effects | – Common: Gastrointestinal disturbances (e.g., nausea, diarrhea), headache, dizziness.<br>- Serious: Hypocalcemia, osteonecrosis of the jaw. |
| Storage Conditions | Store in a cool, dry place, protected from light. |
| Special Considerations | – Monitor calcium levels, especially in patients with renal impairment.<br>- Use with caution in patients with severe renal impairment.<br>- May interact with calcium supplements and antacids. |
| Research and Development | Used in research for bone metabolism studies and as a reference compound for developing new bisphosphonates |
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