Active Pharmaceutical Ingredients

Molecular Weight：720

CAS No.: 14897-39-3

Rifamycin sodium is a kind of broad-spectrum antibiotic, which is a full effect bactericide with strong bactericidal power. It is mainly used for infection caused by Gram-positive bacteria such as Staphylococcus aureus and Mycobacterium tuberculosis, and biliary tract and urinary tract infection caused by gram-negative bacteria.

Description

It is a fine or slightly granular, red powder. It is soluble in water, freely soluble in anhydrous ethanol.

Application

It is an antibiotic drug, which is used for the combined treatment of Mycobacterium tuberculosis infection and severe methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis and refractory Legionella infection, especially for respiratory tract infection, urinary tract infection, skin and soft tissue infection caused by sensitive bacteria. It can also be combined with other antibiotics in the treatment of severe infections caused by sensitive bacteria, such as sepsis, peritonitis, osteomyelitis, etc.

Packing and Storage

Preserve in an airtight container, protected from light at a temperature of 2°C to 8°C. If the substance is sterile, store in a sterile, airtight, tamper-proof container.

Minimum Order

One package

Title	Content
Introduction	Rifamycin Sodium, also known as Rifamycin SV monosodium, is an antibiotic belonging to the ansamycin family. It is isolated from the fermentation of A. mediterranei or its mutants.
Chemical Properties	Molecular formula: C₃₇H₄₆NNaO₁₂; Molecular weight: 719.75; CAS No.: 14897-39-3.
Mechanism of Action	It inhibits bacterial DNA-dependent RNA polymerase, showing broad-spectrum activity against Gram-positive bacteria and some Gram-negative bacteria.
Medical Uses	It is used to treat infections caused by sensitive bacteria, such as tuberculosis and infections caused by methicillin-resistant Staphylococcus aureus (MRSA). It is also under investigation for treating traveler’s diarrhea, irritable bowel syndrome with diarrhea (IBS-D), and acute uncomplicated diverticulitis.
Dosage Forms	Available as an injection for intravenous use. Special formulations like Rifamycin SV-MMX are also being studied for gastrointestinal conditions.
Storage Conditions	Store the powder at -20°C for up to 3 years. In solvent, store at -80°C for 1 year.
Potential Side Effects	Possible adverse reactions include gastrointestinal symptoms (e.g., nausea, vomiting), changes in stool consistency, fever, and alterations in blood and urine tests.

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