Active Pharmaceutical Ingredients

Catalog ID80017028

CAS NO.14897-39-3

Purity 98%

MDL NumberMFCD00056847

EINEC Molecular Formula C37H46NNaO12

Molecular Weight 719.7504

Aspect	Details
Definition	Rifampicin SV Sodium is a semisynthetic antibiotic belonging to the ansamycin class, derived from rifamycin B produced by Streptomyces mediterranei. It is used primarily for its antimicrobial properties.
Mechanism of Action	– It inhibits bacterial RNA synthesis by binding to the β subunit of bacterial DNA-dependent RNA polymerase, preventing transcription.<br>- This mechanism is bactericidal and affects both Gram-positive and Gram-negative bacteria, as well as mycobacteria.
Clinical Uses	– Used for treating infections caused by multidrug-resistant bacteria.<br>- Approved for treating traveler’s diarrhea caused by non-invasive strains of Escherichia coli and other gastrointestinal infections.<br>- Investigated for use in irritable bowel syndrome with diarrhea (IBS-D) and small intestinal bacterial overgrowth (SIBO).
Pharmacokinetics	– Poorly absorbed orally, with a bioavailability of <0.1%.<br>- Distributed primarily in the gastrointestinal tract, with a volume of distribution of 101.8 L.<br>- Metabolized in the liver to a 25-deacetyl metabolite.<br>- Eliminated mainly through feces (90% of the dose), with a half-life of approximately 3 hours.
Dosage Forms	– Available as modified-release tablets designed to release the drug in the distal small intestine and colon.
Storage Conditions	Store at -20°C in a freezer.
Side Effects	Generally well-tolerated, with minimal systemic side effects due to its poor absorption.
Contraindications	Hypersensitivity to rifamycins.
Research Applications	– Investigated for its potential in treating various bacterial infections and its role in preventing antibiotic-associated colitis.<br>- Studied for its efficacy in IBS-D and other intestinal pathologies with infectious components.

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