Rifampicin SV sodium CAS NO.14897-39-3
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Category：Active Pharmaceutical Ingredients MOQ:100KG Shipped directly from China
Introduction
Catalog ID80017028
CAS NO.14897-39-3
Purity 98%
MDL NumberMFCD00056847
EINEC Molecular Formula C37H46NNaO12
Molecular Weight 719.7504
| Aspect | Details |
|---|---|
| Definition | Rifampicin SV Sodium is a semisynthetic antibiotic belonging to the ansamycin class, derived from rifamycin B produced by Streptomyces mediterranei. It is used primarily for its antimicrobial properties. |
| Mechanism of Action | – It inhibits bacterial RNA synthesis by binding to the β subunit of bacterial DNA-dependent RNA polymerase, preventing transcription.<br>- This mechanism is bactericidal and affects both Gram-positive and Gram-negative bacteria, as well as mycobacteria. |
| Clinical Uses | – Used for treating infections caused by multidrug-resistant bacteria.<br>- Approved for treating traveler’s diarrhea caused by non-invasive strains of Escherichia coli and other gastrointestinal infections.<br>- Investigated for use in irritable bowel syndrome with diarrhea (IBS-D) and small intestinal bacterial overgrowth (SIBO). |
| Pharmacokinetics | – Poorly absorbed orally, with a bioavailability of <0.1%.<br>- Distributed primarily in the gastrointestinal tract, with a volume of distribution of 101.8 L.<br>- Metabolized in the liver to a 25-deacetyl metabolite.<br>- Eliminated mainly through feces (90% of the dose), with a half-life of approximately 3 hours. |
| Dosage Forms | – Available as modified-release tablets designed to release the drug in the distal small intestine and colon. |
| Storage Conditions | Store at -20°C in a freezer. |
| Side Effects | Generally well-tolerated, with minimal systemic side effects due to its poor absorption. |
| Contraindications | Hypersensitivity to rifamycins. |
| Research Applications | – Investigated for its potential in treating various bacterial infections and its role in preventing antibiotic-associated colitis.<br>- Studied for its efficacy in IBS-D and other intestinal pathologies with infectious components. |
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