Active Pharmaceutical Ingredients

CAS NO.135062-02-1

Repaglinide is used to treat type II diabetes.

Property	Details
Chemical Name	Repaglinide
CAS Number	135062-02-1
Molecular Formula	\(C_{27}H_{36}N_2O_4\)
Molecular Weight	452.59
Molecular Structure	Repaglinide has a unique structure. It consists of a bicyclic heterocyclic core, with a carboxyl group and several other aliphatic and aromatic side chains attached. The structure allows it to interact specifically with the sulfonylurea receptor on pancreatic beta – cells.
Appearance	Usually appears as a white to off – white crystalline powder.
Solubility	Sparingly soluble in water. It has better solubility in organic solvents like ethanol and methanol. This solubility characteristic is crucial for formulating it into various pharmaceutical dosage forms such as tablets.
Pharmacological Class	Meglitinide class of antidiabetic drugs
Mechanism of Action	Repaglinide binds to the sulfonylurea receptor on pancreatic beta – cells. This binding leads to the closure of potassium channels, depolarization of the cell membrane, and subsequent opening of calcium channels. The influx of calcium ions stimulates the release of insulin granules from the beta – cells. In this way, it helps to lower blood glucose levels by increasing insulin secretion in a glucose – dependent manner.
Medical Applications	Type 2 Diabetes Mellitus: Approved for the treatment of type 2 diabetes. It is used to control blood sugar levels in patients who cannot achieve adequate glycemic control with diet and exercise alone. Repaglinide can be used as monotherapy or in combination with other antidiabetic agents such as metformin. It is particularly useful for patients who have post – meal hyperglycemia, as its short – acting nature allows for better control of blood glucose spikes after eating.
Stability	Stable under normal storage conditions, typically at room temperature in a dry place protected from light. However, exposure to high humidity, extreme temperatures, or strong oxidizing or reducing agents may cause degradation of the drug, which can affect its potency and safety.
Safety Considerations	Common side effects include hypoglycemia, which is more likely to occur when the drug is used inappropriately or in combination with other drugs that can lower blood sugar. Weight gain is also a possible side effect, similar to some other drugs that stimulate insulin secretion. Repaglinide may interact with other medications. For example, drugs that inhibit or induce the cytochrome P450 enzymes (such as some antifungal drugs and rifampin) can affect the metabolism of repaglinide, leading to altered drug levels and potentially increased risk of side effects or reduced efficacy.

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.