Rasagiline
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms (R)-N-(2-Propynyl)-2,3-dihydroinden-1-amine
Catalog ID80078868
CAS NO.136236-51-6 Purity 95+%
MDL NumberMFCD00866571
Molecular Formula C12H13N
Molecular Weight 171.238
| Category | Content |
|---|---|
| Generic Name | Rasagiline |
| Brand Name | Azilect |
| Chemical Formula | C12H14N2O |
| CAS Number | 154554-66-6 |
| Mechanism of Action | Rasagiline is a selective monoamine oxidase B (MAO-B) inhibitor. It increases dopamine levels in the brain by blocking the breakdown of dopamine, thereby improving symptoms of Parkinson’s disease. |
| Indications | – Used as a monotherapy for early-stage Parkinson’s disease.<br>- Used as an adjunct to levodopa in patients with motor fluctuations. |
| Dosage Forms | Tablets (0.5 mg, 1 mg) |
| Administration | – Usual dose: 1 mg once daily.<br>- Take with or without food. |
| Pharmacokinetics | – Absorption: Rapid, with peak plasma concentration reached within 1-2 hours.<br>- Half-life: Approximately 3 hours.<br>- Metabolism: Primarily hepatic. |
| Common Side Effects | – Headache.<br>- Joint pain.<br>- Flu-like symptoms.<br>- Insomnia.<br>- Nausea.<br>- Depression. |
| Serious Side Effects | – Hypertension: Monitor blood pressure regularly.<br>- Serotonin Syndrome: Symptoms include agitation, confusion, fever, tremors, and seizures.<br>- Orthostatic Hypotension: Dizziness or fainting upon standing.<br>- Dyskinesia: Uncontrollable movements when taken with levodopa.<br>- Psychotic-like behaviors: Hallucinations or delusions.<br>- Unusual urges: Increased gambling, sexual behavior, or shopping. |
| Precautions | – Avoid use with other MAOIs or certain antidepressants.<br>- Monitor for signs of hypertension and serotonin syndrome.<br>- Avoid sudden discontinuation.<br>- Use with caution in patients with liver impairment.<br>- Inform your doctor if you are pregnant or breastfeeding. |
| Storage | Store at room temperature, protect from moisture. |
| Developer | Teva Pharmaceuticals |
| Approval Date | Approved by the FDA in 2006. |
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