Rafoxanide
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017909
CAS NO.22662-39-1
Purity 96%
MDL NumberMFCD00682899
EINEC245-148-9
Molecular FormulaC19H11Cl2I2NO3
Molecular Weight 626.0105
Melting point: 168~170°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C19H11Cl2I2NO3<br> Molecular weight: 605.57 g/mol |
| Mechanism of Action | Antiparasitic: Interferes with energy metabolism and inhibits chitinase in helminths, disrupting ATP production and mitochondrial function.<br> Antimicrobial: Inhibits bacterial and fungal histidine kinase enzymes, downregulates resistance genes, and enhances the efficacy of β-lactam and antifungal drugs. |
| Therapeutic Uses | Veterinary: Used to treat parasitic infections in animals.<br> Antimicrobial: Repurposed to combat multidrug-resistant bacterial and fungal infections, including Klebsiella pneumoniae and Candida albicans. |
| Formulations | Available as veterinary formulations. |
| Safety Information | Toxicity: Classified as a potential antimicrobial agent with low toxicity.<br> Drug Interactions: Synergistic effects when combined with colistin, cefotaxime, and fluconazole. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture. |
| Synonyms | Disalan, Flukanide, MK 990, Rafoxanid, Ranide |
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