(R)-(-)-O-Formylmandeloyl chloride
Pharmaceutical Materials 2025-03-02
CAS Number: 29169-64-0
Molecular Formula: C9H7ClO3
Molecular Weight: 198.60 g/mol
Appearance: Light yellow transparent liquid
Boiling Point: 221°C (lit.)
Density: 1.290 g/mL at 20°C (lit.)
Usage: Used as a chemical reagent and intermediate in pharmaceutical synthesis.
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| Attribute | Information |
|---|---|
| Chemical Name | (R)-(-)-O-Formylmandeloyl chloride |
| CAS Number | 64178-66-7 |
| Synonyms | (R)-(-)-2-(Formyloxy)-3-phenylpropionyl chloride; (R)-(-)-α-(Chlorocarbonyl)-β-phenylglyceraldehyde acetate |
| Molecular Formula | C10H9ClO3 |
| Molecular Weight | 212.63 g/mol |
| Appearance | White to off-white crystalline solid |
| Melting Point | 62-64 °C |
| Boiling Point | 294.6 °C (estimated) |
| Density | 1.3 g/cm³ (estimated) |
| Chirality | (R)-(-)-configuration |
| Chemical Structure | Contains a chloride group, a formate ester, and a phenyl ring |
| Solubility | Soluble in organic solvents such as dichloromethane, ethyl acetate, and acetone; insoluble in water |
| Uses | Used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also employed in the preparation of chiral ligands and catalysts. |
| Synthesis Methods | Prepared by the reaction of (R)-(-)-mandelic acid with chloroformates or thionyl chloride in the presence of a base. |
| Health Effects | May cause irritation to skin, eyes, and respiratory tract. Ingestion and inhalation may be harmful. |
| Environmental Considerations | Handle and dispose of (R)-(-)-O-Formylmandeloyl chloride according to local environmental regulations. |
| Safety Precautions | Wear appropriate protective clothing, gloves, and eye protection. Store in a cool, dry place, away from heat, sparks, and open flames. Keep away from oxidizing agents and incompatible materials. |
