(R)-5-broMo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-aMine
Category：Other Pharmaceutical
Introduction
[5-bromo-3- [(1R) – (2,6-dichloro-3-fluorophenyl) ethoxy] pyridin-2-yl] amine, commonly known as BPA, is an organic compound.
BPA is a white solid. It is stable at room temperature, but flammable at high temperatures and sources of ignition. BPA is soluble in organic solvents such as dichloromethane and ether, and can be hydrolyzed under acidic conditions.
BPA is mainly used as a reagent and intermediate in organic synthesis reactions. It can also be used for the preparation of pesticides and dyes.
A common method for preparing BPA is to react 5-bromo-2-pyridineamine with 1- [(2,6-dichloro-3-fluorophenyl) ethoxy] bromoethane.
It should be used in a well ventilated area and appropriate personal protective equipment such as protective gloves, goggles, and clothing should be worn. During operation and storage, contact with oxidants and acidic substances should be avoided. If accidentally inhaled or ingested, seek medical attention immediately. Please conduct specific individual and environmental safety assessments based on the actual situation.
| Name | (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine |
| Synonyms | Crizotinib Impurity 3 (R)-5-broMo-3-[1-(2,6-dichloro-3-fluoropehnyl)ethoxy]pyridin-2-aMine (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-Pyridinamine [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine 2-PyridinaMine, 5-broMo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]- (R)-5-BroMo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylaMine [5-Bromo-3-[[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]oxy]pyridin-2-yl]amine InterMediate Ⅰof Crizotinib (R)-5-broMo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-aMine |
| CAS | 877399-00-3 |
| EINECS | 700-798-7 |
| Molecular Formula | C13H10BrCl2FN2O |
| Molar Mass | 380.04 |
| Density | 1.643 |
| Melting Point | 107.0 to 111.0 °C |
| Boling Point | 423.4±40.0 °C(Predicted) |
| Appearance | powder to crystal |
| Color | White to Light yellow to Light orange |
| pKa | 5.55±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Use | This product is for scientific research only and shall not be used for other purposes. |
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