(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Cas：127852-28-2
Pharmaceutical Materials 2025-03-02
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, with the CAS number 127852-28-2, is a highly valuable chiral alcohol that finds extensive application in the pharmaceutical industry. This compound serves as a crucial intermediate in the synthesis of various drugs, notably the antiemetic Aprepitant, which is used to prevent nausea and vomiting induced by chemotherapy.
The presence of trifluoromethyl groups on the phenyl ring endows it with unique chemical properties, making it an essential building block in organic synthesis. The compound is known for its high purity and stability, ensuring reliable performance in pharmaceutical manufacturing processes.
| Product Properties | Details |
|---|---|
| CAS Number | 127852-28-2 |
| Chemical Name | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol |
| Synonyms | (R)-3,5-bis(trifluoromethyl)-α-methylbenzyl alcohol, (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethanol |
| Molecular Formula | C10H8F6O |
| Molecular Weight | 258.16 g/mol |
| Appearance | White to almost white powder or crystal |
| Melting Point | 55 °C |
| Boiling Point | 175.8 ± 35.0 °C (at 760 mmHg) |
| Density | 1.4 ± 0.1 g/cm³ |
| Flash Point | 60.1 ± 25.9 °C |
| Refractive Index | 1.418 |
| Usage | Pharmaceutical intermediate, particularly in the synthesis of Aprepitant |
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