Pyridine-3-boronic acid
Biomedicine 2025-03-04
CAS.No：1692-25-7
Appearance:White powder
Molecular Formula:C5H6BNO2
Purity:HPLC≥99.5%
Molecular weight:122.92
Capacity:20 tons/month
Basic Information of Pyridine-3-Boronic Acid
| Aspect | Details |
|---|---|
| Chemical Name | Pyridine-3-Boronic Acid |
| CAS Number | 1692-25-7 |
| Molecular Formula | C₅H₆BNO₂ |
| Molecular Weight | 122.92 g/mol |
| Appearance | Pale yellow to yellow-brown solid |
| Melting Point | >300°C (lit.) |
| Density | 1.22±0.1 g/cm³ (Predicted) |
| Solubility | Slightly soluble in methanol |
| Storage Conditions | Store in a cool, dry place under inert gas (nitrogen or argon) |
| pKa | 4.00±0.10 (Predicted) |
Additional Information on Pyridine-3-Boronic Acid
| Aspect | Details |
|---|---|
| Synonyms | 3-Pyridylboronic Acid, Pyridine-3-Boronic Acid, 3-Pyridinylboronic Acid |
| Applications | – Suzuki-Miyaura Cross-Coupling Reactions: Used as a reagent for phosphine-free Suzuki-Miyaura cross-coupling reactions.<br>- Regioselective Coupling: Used in regioselective Suzuki-Miyaura coupling and tandem palladium-catalyzed intramolecular aminocarbonylation and annulation.<br>- N-Arylation: Used in N-arylation reactions with copper acetylacetonate catalyst.<br>- Cyanation: Used in copper-mediated cyanation and regioselective cyanation of electron-rich benzenes.<br>- Polymer Synthesis: Used to prepare new linear poly(phenylpyridyl) chains by Suzuki coupling.<br>- Pharmaceuticals: Used in the synthesis of various therapeutic enzymatic and kinase inhibitors and receptor antagonists. |
| Safety Information | – Hazard Codes: Xn (Harmful), Xi (Irritant).<br>- Risk Statements: R22 (Harmful if swallowed), R36/37/38 (Irritating to eyes, respiratory system, and skin).<br>- Safety Statements: S26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice), S36/37/39 (Wear suitable protective clothing, gloves, and eye/face protection).<br>- Storage: Store in a cool, dry place under inert gas. |
| Packaging and Price | – 5g: $227.50.<br>- 1g: $77.60.<br>- Bulk: Available from various suppliers. |
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