Pyrazine

Pharmaceutical Materials 2025-03-02

CAS Number: 290-37-9

Molecular Formula: C4H4N2

Molecular Weight: 80.09 g/mol

Appearance: Colorless crystals

Melting Point: 52°C

Boiling Point: 115°C

Density: 1.031 g/cm³

Usage: Used as an intermediate in pharmaceuticals, perfumes, and dyes.

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

 

Attribute Details
Name Pyrazine
Synonyms 1.4-Diazine, p-Diazine, Paradiazine, Pyrazin, 2.5-Diazabicyclo[2.2.2]octane (inactive isomer)
CAS Number 290-37-9
Molecular Formula C4H4N2
Molecular Weight 80.09 g/mol
Chemical Structure Heterocyclic compound with two nitrogen atoms at positions 1 and 4
Appearance Colorless crystals
Physical Properties
  • Melting Point: 52-54°C
  • Boiling Point: 115°C
  • Density: 1.031 g/cm³ at 25°C
  • Flash Point: 55°C
  • Soluble in water, ethanol, and ether
Chemical Properties
  • Weakly basic
  • Stable
  • Resistant to electrophilic substitution
  • Reactive towards nucleophiles
  • Aromaticity similar to pyridine but with weaker alkalinity
Uses
  • Intermediate in pharmaceuticals, perfumes, and dyes
  • Component in food flavorings
  • Synthesis of various chemical compounds
  • Ligand in material science for constructing crystalline materials
Synthesis Methods
  • Industrially produced by dehydrogenation of ethanolamine under gas-phase catalytic conditions
  • Synthesis by high-temperature dehydrogenation of β-hydroxyethylaminoethylamine or N-hydroxyethylethylenediamine in the presence of Ni/Al2O3
Safety Information
  • Flammable
  • May cause skin and eye irritation
  • Inhalation may cause respiratory irritation
  • Keep away from heat, sparks, and open flames
  • Wear appropriate protective clothing, gloves, and eye protection
  • Follow relevant safety regulations and guidelines