Proglumetacin CAS NO.57132-53-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017059
CAS NO.57132-53-3
Purity 99%
MDL NumberMFCD00866080
EINEC Molecular FormulaC46H58ClN5O8
Molecular Weight844.4344
| Aspect | Details |
|---|---|
| Definition | Proglumetacin is a non-steroidal anti-inflammatory drug (NSAID) that is metabolized to indometacin and proglumide. |
| Mechanism of Action | – Acts as an orally active and potent cyclo-oxygenase inhibitor.<br>- Inhibits SARS-CoV Mpro (main protease of SARS-CoV-2) with an AC50 of 8.9 μM. |
| Clinical Uses | – Used to manage pain and inflammation associated with musculoskeletal and joint disorders.<br>- Indicated for conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. |
| Pharmacokinetics | – Metabolized in the body to indometacin and proglumide.<br>- Proglumide helps prevent injury to the stomach lining. |
| Physical Properties | – Molecular Formula: C₄₆H₅₈ClN₅O₈.<br>- Molecular Weight: 844.4 g/mol.<br>- CAS Number: 57132-53-3. |
| Storage Conditions | – Shipping with blue ice. |
| Synonyms | – Proglumetacina.<br>- Proglumetacine.<br>- Proglumetacinum.<br>- Prodamox.<br>- Protaxon. |
| Potential Side Effects | – Information on side effects is limited, but common NSAID side effects may include gastrointestinal disturbances, headache, and dizziness. |
| Drug Interactions | – May interact with other drugs; for example, it may decrease the excretion rate of Abacavir, leading to higher serum levels.<br>- Can increase the risk of bleeding when combined with Abciximab. |
| Research Applications | – Investigated for its potential anti-inflammatory effects in conditions like allergic air pouch inflammation.<br>- Studied for its inhibitory effects on SARS-CoV-2 Mpro, indicating potential antiviral activity |
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