Procarbazine HCl CAS NO.366-70-1
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017217
CAS NO.366-70-1
Purity 98%
MDL NumberMFCD00072082
Molecular FormulaC12H19N3O.HCl
Molecular Weight257.7597
Melting point: 223~226°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C12H20ClN3O<br>- Molecular Weight: 261.76 g/mol<br>- CAS Number: 366-70-1<br>- Melting Point: 225-228°C<br>- Solubility: Soluble in water |
| Mechanism of Action | Procarbazine HCl is an alkylating agent that exerts its cytotoxic effects by forming cytotoxic metabolites, such as methylhydrazine and azoxy derivatives, which can bind covalently to DNA and other cellular components. |
| Indications | – Treatment of Hodgkin’s lymphoma as part of combination chemotherapy.<br>- Other off-label uses may include the treatment of certain types of brain tumors. |
| Pharmacokinetics | – Absorption: Rapidly and nearly completely absorbed from the gastrointestinal tract.<br>- Distribution: Crosses the blood-brain barrier and distributes into cerebrospinal fluid.<br>- Metabolism: Primarily metabolized in the liver and kidneys.<br>- Excretion: Approximately 45% to 70% of a dose is excreted in the urine within the first 24 hours. |
| Adverse Effects | – Common: Nausea, vomiting, bone marrow suppression, fatigue.<br>- Serious: Severe myelosuppression, hepatotoxicity. |
| Contraindications | – Hypersensitivity to procarbazine.<br>- Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs. |
| Special Considerations | – Monitor blood counts regularly due to risk of bone marrow suppression.<br>- Use with caution in patients with liver or kidney impairment.<br>- Avoid alcohol and foods high in tyramine due to the risk of hypertensive crisis when used with MAOIs. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
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