Procaine HCl CAS NO.51-05-8
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017472
CAS NO.51-05-8
Purity 99%
MDL NumberMFCD00013000
EINEC200-077-2
Molecular formula C13H20N2O2.HCl
Molecular weight 272.771
Melting point: 154~158℃
Boiling point: 195~196℃ (17mmHg)
| Aspect | Details |
|---|---|
| Mechanism of Action | Procaine HCl is a local anesthetic that works by blocking voltage-gated sodium channels in nerve cells, preventing the propagation of nerve impulses. |
| Indications | – Local anesthesia for minor surgical procedures.<br>- Used for local infiltration and peripheral nerve block.<br>- Not intended for spinal or epidural anesthesia. |
| Pharmacokinetics | – Rapidly absorbed from the injection site.<br>- Metabolized in the liver to para-aminobenzoic acid (PABA) and other metabolites.<br>- Excreted primarily in urine. |
| Dosage Forms | Available as sterile solutions in concentrations of 1% and 2% for injection. |
| Administration | – For local infiltration: 0.25% to 0.5% solutions, up to 350-600 mg total dose.<br>- For peripheral nerve blocks: 0.5%, 1%, and 2% solutions, up to 200 mL, 100 mL, and 50 mL, respectively.<br>- For neuraxial anesthesia: 10% solution, doses ranging from 50 to 200 mg. |
| Adverse Effects | – Hypersensitivity reactions (e.g., urticaria, pruritus, erythema, laryngeal edema).<br>- Systemic toxicity (LAST) can cause cardiac (e.g., arrhythmias, heart failure) and neurological (e.g., seizures, coma) effects.<br>- Other side effects include nausea, vomiting, dizziness, and syncope. |
| Contraindications | – Hypersensitivity to procaine or its components.<br>- Patients with cardiac, renal, or hepatic impairment.<br>- Myasthenia gravis.<br>- Pseudocholinesterase deficiency.<br>- Systemic lupus erythematosus (SLE).<br>- Pregnancy and breastfeeding. |
| Special Considerations | – Use with caution in elderly or acutely ill patients.<br>- Monitor for signs of systemic toxicity, especially in patients with reduced metabolism.<br>- Avoid use in patients with a history of PABA allergy. |
| Storage Conditions | Store at room temperature, away from light and moisture |
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