Procainamide HCl
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80020957
CAS NO.614-39-1
Purity 98%
MDL NumberMFCD00012998
EINEC210-381-7
Molecular formula C13H22ClN3O
Molecular weight 271.7863
Melting point: 166~170°C
| Category | Information |
|---|---|
| Chemical Properties | Procainamide HCl is the hydrochloride salt form of procainamide, an amide derivative with the molecular formula C₁₃H₂₂ClN₃O and a molecular weight of 295.8. It is a white to tan, hygroscopic, odorless crystalline powder. |
| Solubility | Soluble in water, alcohol, and chloroform; practically insoluble in ether and benzene. |
| Mechanism of Action | Procainamide is a Class 1A antiarrhythmic agent that binds to fast sodium channels, inhibiting recovery after repolarization. It prolongs the action potential, reduces impulse conduction speed, and decreases myocardial excitability and contractility. |
| Clinical Uses | – Treatment of ventricular arrhythmias, supraventricular arrhythmias, atrial flutter, atrial fibrillation, AV nodal re-entrant tachycardia, and Wolff-Parkinson-White syndrome.<br>- Used for chemical cardioversion in atrial flutter and atrial fibrillation.<br>- Effective in terminating ventricular tachycardia in patients with structural heart disease. |
| Administration | – IV Loading Dose: 10-17 mg/kg at a rate of 20-50 mg/min.<br>- Maintenance Dose: 1-4 mg/min.<br>- Oral Dosing: 50 mg/kg/24 hours divided into doses every 6 hours. |
| Adverse Effects | – Cardiovascular: Bradycardia, hypotension, torsades de pointes, ventricular fibrillation.<br>- Immunologic: Drug-induced lupus erythematosus-like syndrome.<br>- Hematologic: Pancytopenia, agranulocytosis.<br>- Other: Nausea, vomiting, diarrhea, abdominal pain. |
| Contraindications | – Complete heart block.<br>- Torsades de pointes.<br>- Hypersensitivity to procainamide.<br>- Active lupus erythematosus. |
| Precautions | – Use with caution in patients with bronchial asthma or myasthenia gravis.<br>- Monitor for prolonged QRS, QTc, and PR intervals during treatment.<br>- Consider hepatic impairment when dosing. |
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