Active Pharmaceutical Ingredients

Catalog ID80017213

CAS NO.19237-84-4

Purity 98%

MDL NumberMFCD00058177

EINEC Molecular FormulaC19H21N5O4.HCl

Molecular Weight 419.8621

Melting point: 273~282°C

Aspect	Details
Chemical Properties	– Molecular Formula: C19H21N5O4<br>- Molecular Weight: 419.87 g/mol<br>- CAS Number: 19237-84-4<br>- Physical Appearance: White, crystalline substance
Mechanism of Action	– Prazosin is a selective α1-adrenergic receptor antagonist that causes vasodilation by blocking the action of noradrenaline on vascular smooth muscle, leading to decreased blood pressure.<br>- It also crosses the blood-brain barrier and may modulate sleep patterns, making it useful for PTSD-related nightmares.
Indications	– Treatment of hypertension (high blood pressure).<br>- Management of benign prostatic hyperplasia (BPH).<br>- Treatment of PTSD, particularly for nightmares and sleep disturbances.<br>- Used in Raynaud’s syndrome.
Pharmacokinetics	– Absorption: Oral bioavailability of 50-70%, peak plasma concentration reached in 1-3 hours.<br>- Distribution: Volume of distribution 0.5-1.5 L/kg, highly protein-bound (97%).<br>- Metabolism: Metabolized in the liver via demethylation and conjugation.<br>- Excretion: Half-life of 2-3 hours, primarily excreted in bile and feces.
Dosage Forms	– Oral capsules available in 1 mg, 2 mg, and 5 mg.
Administration	– Hypertension: Initial dose 1 mg three times daily, maintenance dose 1-20 mg/day.<br>- BPH: Initial dose 1 mg three times daily, maintenance dose 2-10 mg/day.<br>- PTSD: Initial dose 1 mg at bedtime, titrated up to 3-15 mg/day.<br>- Raynaud’s Syndrome: Initial dose 0.5 mg twice daily, maintenance dose 1-2 mg twice daily.
Adverse Effects	– Common: Dizziness, headache, drowsiness, nausea.<br>- Serious: First-dose hypotension, orthostatic hypotension, syncope, priapism.<br>- Other: Palpitations, weakness, depression.
Contraindications	– Hypersensitivity to prazosin or other quinazolines.
Special Considerations	– Use with caution in patients with liver or heart disease.<br>- Monitor blood pressure closely, especially during initial dosing.<br>- May cause intraoperative floppy iris syndrome (IFIS) during cataract surgery.
Storage Conditions	Store in a cool, dry place, protected from light and moisture

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