Ponazuril
We are a manufacturer based in China, specializing in high-quality Ponazuril for industrial clients worldwide. Technical support and custom formulation available.
Category：Active Pharmaceutical Ingredients | Brand：MT
Factory Direct
7-30 Days Lead Time
MOQ: 100KG
Global Export
Introduction
Catalog ID80071759
CAS NO.69004-04-2
Purity 98%
MDL NumberMFCD09263475
Molecular FormulaC18H14F3N3O6S
Molecular Weight 457.384
Melting point: 241~246°C
| Item | Information |
|---|---|
| Mechanism of Action | Ponazuril is a triazine-based antiprotozoal drug and a metabolite of toltrazuril. It acts by inhibiting enzyme systems in protozoa and/or decreasing pyrimidine synthesis, specifically targeting the apicoplast organelle in apicomplexan parasites. |
| Indications | – Approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by Sarcocystis neurona.<br>- Used in small animals (cats, dogs, rabbits) for treating coccidiosis. |
| Dosage Forms | Available as an oral paste (Marquis) for horses. |
| Common Dosage | – For EPM in horses: 5 mg/kg once daily for a minimum of 28 days.<br>- For coccidiosis in small animals: Doses range from 20 to 50 mg/kg for 2 to 5 days. |
| Pharmacokinetics | – Achieves steady-state concentrations in horse cerebrospinal fluid (CSF) after about one week.<br>- Half-life in horses is approximately 1.6 to 4.5 days. |
| Efficacy | – Approximately 60% efficacy in treating EPM in horses.<br>- Effective at blocking merozoite production in vitro at concentrations of 1 µg/mL. |
| Special Notes | – An initial loading dose (e.g., 15 mg/kg) may be used to achieve therapeutic concentrations more quickly in horses.<br>- Treatment duration may be extended beyond 28 days based on clinical response. |
| Trade Names | Marquis (oral paste for horses). |
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