Active Pharmaceutical Ingredients

Catalog ID80071759

CAS NO.69004-04-2

Purity 98%

MDL NumberMFCD09263475

Molecular FormulaC18H14F3N3O6S

Molecular Weight 457.384

Melting point: 241~246°C

Item	Information
Mechanism of Action	Ponazuril is a triazine-based antiprotozoal drug and a metabolite of toltrazuril. It acts by inhibiting enzyme systems in protozoa and/or decreasing pyrimidine synthesis, specifically targeting the apicoplast organelle in apicomplexan parasites.
Indications	– Approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by Sarcocystis neurona.<br>- Used in small animals (cats, dogs, rabbits) for treating coccidiosis.
Dosage Forms	Available as an oral paste (Marquis) for horses.
Common Dosage	– For EPM in horses: 5 mg/kg once daily for a minimum of 28 days.<br>- For coccidiosis in small animals: Doses range from 20 to 50 mg/kg for 2 to 5 days.
Pharmacokinetics	– Achieves steady-state concentrations in horse cerebrospinal fluid (CSF) after about one week.<br>- Half-life in horses is approximately 1.6 to 4.5 days.
Efficacy	– Approximately 60% efficacy in treating EPM in horses.<br>- Effective at blocking merozoite production in vitro at concentrations of 1 µg/mL.
Special Notes	– An initial loading dose (e.g., 15 mg/kg) may be used to achieve therapeutic concentrations more quickly in horses.<br>- Treatment duration may be extended beyond 28 days based on clinical response.
Trade Names	Marquis (oral paste for horses).

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