Pomalidomide-PEG4-Ph-NH2
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Category：Biomedicine
Introduction
CAS NO.: 1818885-63-0
Product purity: ≥95%
Molecular formula: C27H32N4O8
Molecular weight: 540.57
Product Usage: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as in ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Pomalidomide-PEG4-Ph-NH2 |
| CAS Number | 1818885-63-0 |
| Molecular Formula | C27H32N4O8 |
| Molecular Weight | 540.57 g/mol |
| Purity | ≥98% |
| Appearance | White to light yellow solid or powder |
| Solubility | Soluble in DMSO (50 mg/mL), insoluble in water (<0.1 mg/mL) |
| Storage Conditions | Powder: -20°C for 3 years; In solvent: -80°C for 1 year, -20°C for 1 year |
Detailed Information
| Item | Description |
|---|---|
| Structure | Contains a Pomalidomide-based cereblon ligand and a 4-unit PEG linker with a phenylamine (Ph-NH2) group at the end |
| Reactivity | The phenylamine group can react with carboxyl groups to form amide bonds or with aldehydes to form Schiff bases |
| Applications | – PROTAC Technology: Used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.<br>- Medical Research: Applied in drug release, nanotechnology, and cell culture.<br>- Material Science: Used in the synthesis of functional coatings and polymers. |
| Advantages | – Combines the properties of Pomalidomide, PEG, and a reactive phenylamine group.<br>- High biocompatibility and versatility in bioconjugation. |
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