Polymyxin B sulphate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS NO.:1405-20-5
Molecular formula:C56H98N16O13.H2SO4
Molecular weight:1301.56
Standard:USP,BP,EP
Packaging:125G/TIN;1KG/TIN
Polymyxin B Sulphate: A Potent Antibacterial Agent
Polymyxin B sulphate is a significant antibiotic used in treating specific bacterial infections.
1. General and Pharmacokinetic Information
| Aspect | Details |
| Source | Produced by Bacillus polymyxa |
| Chemical Class | Cyclic polypeptide antibiotic |
| Administration | Usually intravenous; can be topical in some cases |
| Distribution | Mainly in extracellular fluids; limited CNS penetration |
| Metabolism | Not extensively metabolized |
| Elimination | Primarily excreted in urine, with a ~6 – hour half – life |
2. Mechanism of Action
| Action | Explanation |
| Membrane Interaction | Binds to lipopolysaccharides (LPS) in the outer membrane of Gram – negative bacteria, disrupting its integrity and increasing permeability |
| Cytoplasmic Membrane Disruption | Inserts into the cytoplasmic membrane, causing leakage of intracellular components like potassium ions, leading to cell death |
3. Clinical Applications and Adverse Effects
| Category | Details |
| Clinical Applications | Treats severe Gram – negative bacterial infections, especially those resistant to other antibiotics. Effective against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, etc. Commonly considered for hospital – acquired infections in intensive care units with multi – drug resistant Gram – negative bacteria |
| Adverse Effects | Nephrotoxicity (common, can cause acute kidney injury, especially with high doses or long – term use; renal function monitoring is crucial), Neurotoxicity (frequent, with manifestations like paresthesia, dizziness, and in severe cases, neuromuscular blockade affecting respiration), Allergic Reactions (range from mild rashes to severe anaphylaxis) |
Polymyxin B sulphate is a valuable tool against Gram – negative bacteria, yet its use must be carefully weighed due to potential side effects.
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