Polydatin
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80019099
CAS NO.65914-17-2
Purity 95%
MDL NumberMFCD00210592
Molecular Formula C20H22O8
Molecular Weight 390.38
Melting point: 223~226°C
| Category | Details |
|---|---|
| Chemical Properties | Polydatin (also known as Piceid) is a stilbene glycoside with the molecular formula C20H22O9 and a molecular weight of 406.4. |
| Physical Properties | It is a white crystalline powder, soluble in ethanol and water. |
| Biological Activities | Anticancer Effects: Inhibits cell proliferation and induces apoptosis in various cancer cell lines, including colorectal cancer, leukemia, and ovarian cancer.<br> Hepatoprotective Effects: Reduces liver damage by inhibiting oxidative stress and inflammation, and activating Nrf2-related signaling.<br> Renal Protective Effects: Protects against kidney damage by activating the Nrf2 signaling pathway and inhibiting NF-κB/NLRP3 inflammasome activity.<br> Effects on Respiratory System: Reduces inflammation and oxidative stress in lung tissues, and inhibits TGF-β1/Smad3 signaling pathway.<br> Effects on Rheumatoid Diseases: Reduces inflammation and NET formation in rheumatoid arthritis and systemic lupus erythematosus. |
| Mechanism of Action | Anticancer: Inhibits cancer cell proliferation and induces apoptosis through various pathways, including the miR-382/PD-L1 axis and the BMP signaling pathway.<br> Hepatoprotective: Reduces oxidative stress and inflammation by inhibiting NF-κB and activating Nrf2/HO-1 signaling.<br> Renal Protective: Inhibits NF-κB/NLRP3 inflammasome activity and activates the Nrf2 signaling pathway.<br> Respiratory System: Inhibits TGF-β1/Smad3 signaling and reduces oxidative stress.<br> Rheumatoid Diseases: Reduces NET formation and inhibits the IL-6/STAT3/IL-17/NF-κB pathway. |
| Applications | Used in the treatment of cancer, liver diseases, kidney diseases, respiratory disorders, and rheumatoid diseases. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
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